Fenilacetil-KoA 1,2-epoksidaza
| Fenilacetil-KoA 1,2-epoksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.149 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fenilacetil-KoA 1,2-epoksidaza (EC 1.14.13.149, ring 1,2-fenilacetil-KoA epoksidaza, fenilacetil-KoA monooksigenaza, PaaAC, PaaABC(D)E) je enzim sa sistematskim imenom fenilacetil-KoA:kiseonik oksidoreduktaza (1,2-epoksidacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fenilacetil-KoA + NADPH + H+ + O2 2-(1,2-epoksi-1,2-dihidrofenil)acetil-KoA + NADP+ + H2O
Ovaj enzim učestvuje u aerobnom katabolizmu fenilacetata kod Escherichia coli i Pseudomonas putida.
Reference[уреди | уреди извор]
- ^ Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. (2010). „Bacterial phenylalanine and phenylacetate catabolic pathway revealed”. Proc. Natl. Acad. Sci. USA. 107: 14390—14395. PMID 20660314.
- ^ Grishin, A.M., Ajamian, E., Zhang, L. and Cygler, M. (2010). „Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66: 1045—1049. PMID 20823522.
- ^ Grishin, A.M., Ajamian, E., Tao, L., Zhang, L., Menard, R. and Cygler, M. (2011). „Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex”. J. Biol. Chem. 286: 10735—10743. PMID 21247899.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Phenylacetyl-CoA+1,2-epoxidase на US National Library of Medicine Medical Subject Headings (MeSH)
