Nitronat monooksigenaza
| Nitronat monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.12.16 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Nitronat monooksigenaza (EC 1.13.12.16, NMO) je enzim sa sistematskim imenom nitronat:kiseonik 2-oksidoreduktaza (formira nitrit).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- etilnitronat + O2 acetaldehid + nitrit + drugi produkti
Enzimi iz gljiva Neurospora crassa i kvasca Williopsis saturnus var. mrakii sadrže nekovalentno vezani FMN kao kofaktor.
Reference[уреди | уреди извор]
- ^ Francis, K., Russell, B. and Gadda, G. (2005). „Involvement of a flavosemiquinone in the enzymatic oxidation of nitroalkanes catalyzed by 2-nitropropane dioxygenase”. J. Biol. Chem. 280: 5195—5204. PMID 15582992.
- ^ Ha, J.Y., Min, J.Y., Lee, S.K., Kim, H.S., Kim do, J., Kim, K.H., Lee, H.H., Kim, H.K., Yoon, H.J. and Suh, S.W. (2006). „Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate. Identification of the catalytic base”. J. Biol. Chem. 281: 18660—18667. PMID 16682407.
- ^ Gadda, G. & Francis, K. (2010). „Nitronate monooxygenase, a model for anionic flavin semiquinone intermediates in oxidative catalysis”. Arch. Biochem. Biophys. 493: 53—61. PMID 19577534.
- ^ Francis, K. & Gadda, G. (2009). „Kinetic evidence for an anion binding pocket in the active site of nitronate monooxygenase”. Bioorg. Chem. 37: 167—172. PMID 19683782.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Nitronate+monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
