Taksadien-5a-ol O-acetiltransferaza
| Taksadien-5a-ol O-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.162 | ||||||||
| CAS broj | 229032-29-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Taksadien-5a-ol O-acetiltransferaza (EC 2.3.1.162, acetil koenzim A:taksa-4(20),11(12)-dien-5alfa-ol O-acetil transferaza) je enzim sa sistematskim imenom acetil-KoA:taksa-4(20),11-dien-5alfa-ol O-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- acetil-KoA + taksa-4(20),11-dien-5alfa-ol KoA + taksa-4(20),11-dien-5alfa-il acetat
Ovo je treći enzim biosinteze diterpenoidnog antineoplastičnog leka taksola (paklitaksela).
Reference[уреди | уреди извор]
- ^ Walker, K., Ketchum, R.E., Hezari, M., Gatfield, D., Goleniowski, M., Barthol, A. and Croteau, R. (1999). „Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis”. Arch. Biochem. Biophys. 364: 273—9. PMID 10190984.
- ^ Walker, K., Schoendorf, A. and Croteau, R. (2000). „Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli”. Arch. Biochem. Biophys. 374: 371—380. PMID 10666320.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Taxadien-5alpha-ol+O-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
