UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza
| UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.203 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza (EC 2.3.1.203, PglD) je enzim sa sistematskim imenom acetil-KoA:UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin KoA + UDP-N,N'-diacetilbacillosamin
Produkt, UDP-N,N'-diacetilbacilosamin, je intermedijer pri glikozilaciji proteina kod nekoliko bakterijskih vrsta.
Reference[уреди | уреди извор]
- ^ Olivier, N.B., Chen, M.M., Behr, J.R. and Imperiali, B. (2006). „In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system”. Biochemistry. 45: 13659—13669. PMID 17087520.
- ^ Rangarajan, E.S., Ruane, K.M., Sulea, T., Watson, D.C., Proteau, A., Leclerc, S., Cygler, M., Matte, A. and Young, N.M. (2008). „Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni”. Biochemistry. 47: 1827—1836. PMID 18198901.
- ^ Hartley, M.D., Morrison, M.J., Aas, F.E., Borud, B., Koomey, M. and Imperiali, B. (2011). „Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N′-diacetylbacillosamine”. Biochemistry. 50: 4936—4948. PMID 21542610.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine+N-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
