OpisMonosodium Urate Crystals in Tophaceous Gout (4306256393).jpg
Squash prep of pasty white material that exuded from foot wound. Compensated polarized light microscopy.
In this case, the podiatrist first sent a biopsy of the wound in formalin, with no history. Of course, the urates dissolved in processing, and the biopsy was nondiagnostic. So, I suggested she just pick up some of the goo, and we could smear it on the slide. Voila! Gout!
Note that the color of the needle-like crystals depends on how they are oriented in respect to the axis of polarization.
Pathological and histological images courtesy of Ed Uthman at flickr.
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