Riboza 5-fosfat — разлика између измена

Riboza 5-fosfat
Nazivi
	IUPAC naziv (2,3,4-Trihydroxy-5-oxo-pentoxy)phosphonic acid
Identifikacija
CAS broj	3615-55-2;
3D model (Jmol)	interaktivna slika;
ECHA InfoCard	100.022.101
MeSH	riboza-5-fosfat
PubChem C ID	230;
	SMILES C(C(C(C(C=O)O)O)O)OP(=O)(O)O; ; ; ; ; ;
Svojstva
Hemijska formula	C5H11O8P
Molarna masa	230,110
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

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Инлајн

Верзија на датум 6. мај 2010. у 06:53

Riboza 5-fosfat je proizvod i intermedijar pentozno fosfatnog puta^[3]^[4]. Zadnji stupanj oksidativnih reakcija pentozno fosfatnog puta je proizvodnja ribuloza 5-fosfata. U zavisnosti od stanja tela, ribuloza 5-fosfat može podleći revizibilnoj izomerizaciji u riboza 5-fosfat ^[5]^[6]. Ribuloza 5-fosfat može alternativno podleći seriji izomerizacija kao i transaldolacija i transketolacija koje rezultiraju u produkciji drugih pentozo fosfata, kao i fruktoza 6-fosfata i gliceraldehid-3-fosfata (koji su intermedijari u glikolizi)^[7].

Enzim riboza-fosfat difosfokinaza^[8] pretvara riboza 5-fosfat u fosforibozil pirofosfat.

Literatura

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ „Pentose phosphate pathway (hexose monophosphate shunt)”.
^ Wamelink MM, Struys EA, Jakobs C (2008). „The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review”. J Inherit Metab Dis. 31: 703—17. PMID 18987987.
^ Zhang, R; Andersson, CE; Savchenko, A; Skarina, T; Evdokimova, E; Beasley, S; Arrowsmith, CH; Edwards, AM; Joachimiak, A (2003). „Structure of Escherichia coli Ribose-5-Phosphate IsomeraseA Ubiquitous Enzyme of the Pentose Phosphate Pathway and the Calvin Cycle”. Structure. 11 (1): 31. PMC 2792023 . PMID 12517338. doi:10.1016/S0969-2126(02)00933-4.
^ Jung, Ch; Hartman, Fc; Lu, Ty; Larimer, Fw (2000). „D-ribose-5-phosphate isomerase from spinach: heterologous overexpression, purification, characterization, and site-directed mutagenesis of the recombinant enzyme”. Archives of biochemistry and biophysics. 373 (2): 409—17. ISSN 0003-9861. PMID 10620366. doi:10.1006/abbi.1999.1554. Непознати параметар |month= игнорисан (помоћ)
^ Horecker B. L., Smyrniotis P. Z., Seegmiller J. E. (1951). „The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate”. J. Biol. Chem. 193 (1): 383–96. PMID 14907726.
^ Diethmar S (2007). Handbook of Enzymes (2 изд.). Springer. стр. 1—22. ISBN 978-3-540-71525-2. doi:10.1007/978-3-540-71526-9_1.

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[Pentose_phosphate_pathway-3] „Pentose phosphate pathway (hexose monophosphate shunt)”.

[Wamelink-4] Wamelink MM, Struys EA, Jakobs C (2008). „The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review”. J Inherit Metab Dis. 31: 703—17. PMID 18987987.

[5] Zhang, R; Andersson, CE; Savchenko, A; Skarina, T; Evdokimova, E; Beasley, S; Arrowsmith, CH; Edwards, AM; Joachimiak, A (2003). „Structure of Escherichia coli Ribose-5-Phosphate IsomeraseA Ubiquitous Enzyme of the Pentose Phosphate Pathway and the Calvin Cycle”. Structure. 11 (1): 31. PMC 2792023 . PMID 12517338. doi:10.1016/S0969-2126(02)00933-4.

[Jung-6] Jung, Ch; Hartman, Fc; Lu, Ty; Larimer, Fw (2000). „D-ribose-5-phosphate isomerase from spinach: heterologous overexpression, purification, characterization, and site-directed mutagenesis of the recombinant enzyme”. Archives of biochemistry and biophysics. 373 (2): 409—17. ISSN 0003-9861. PMID 10620366. doi:10.1006/abbi.1999.1554. Непознати параметар |month= игнорисан (помоћ)

[7] Horecker B. L., Smyrniotis P. Z., Seegmiller J. E. (1951). „The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate”. J. Biol. Chem. 193 (1): 383–96. PMID 14907726.

[Ribose-phosphate_diphosphokinase-8] Diethmar S (2007). Handbook of Enzymes (2 изд.). Springer. стр. 1—22. ISBN 978-3-540-71525-2. doi:10.1007/978-3-540-71526-9_1.

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