Sigma-1 receptor — разлика између измена
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м Нова страница: {{PBB|geneid=10280}} '''Sigma-1 receptor''' (-{''σ<sub>1</sub>R''}-) je šaperonski protein na [[Endoplazmatični retikulum|endoplazmatičnom retik... |
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'''Sigma-1 receptor''' (-{''σ<sub>1</sub>R''}-) je [[Šaperon (protein)|šaperonski protein]] na [[Endoplazmatični retikulum|endoplazmatičnom retikulumu]] (ER) koji moduliše [[kalcijumska signalizacija|kalcijumsku signalizaciju]] putem [[Inozitol trifosfatni receptor|-{IP3}- receptora]].<ref name="Hayashi">{{cite journal | author = Hayashi T, Su TP | year = 2007 | title = Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca<sup>2+</sup> signaling and cell survival. | journal = Cell | volume = 131 | issue = 3 | pages =596–610 | pmid = 17981125 | doi = 10.1016/j.cell.2007.08.036 | url = }}</ref> Sigma-1 receptor je kod čoveka kodiran {{Gene|SIGMAR1}} [[gen]]om.<ref name="pmid8954936">{{cite journal | author = Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V | title = Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1) | journal = Biochem. Biophys. Res. Commun. | volume = 229 | issue = 2 | pages = 553–8 | year = 1996 | month = December | pmid = 8954936 | doi = 10.1006/bbrc.1996.1842 | url = | issn = }}</ref><ref name="pmid9453537">{{cite journal | author = Prasad PD, Li HW, Fei YJ, Ganapathy ME, Fujita T, Plumley LH, Yang-Feng TL, Leibach FH, Ganapathy V | title = Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene | journal = J. Neurochem. | volume = 70 | issue = 2 | pages = 443–51 | year = 1998 | month = February | pmid = 9453537 | doi = 10.1046/j.1471-4159.1998.70020443.x| url = | issn = }}</ref> |
'''Sigma-1 receptor''' (-{''σ<sub>1</sub>R''}-) je [[Šaperon (protein)|šaperonski protein]] na [[Endoplazmatični retikulum|endoplazmatičnom retikulumu]] (ER) koji moduliše [[kalcijumska signalizacija|kalcijumsku signalizaciju]] putem [[Inozitol trifosfatni receptor|-{IP3}- receptora]].<ref name="Hayashi">{{cite journal | author = Hayashi T, Su TP | year = 2007 | title = Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca<sup>2+</sup> signaling and cell survival. | journal = Cell | volume = 131 | issue = 3 | pages =596–610 | pmid = 17981125 | doi = 10.1016/j.cell.2007.08.036 | url = }}</ref> Sigma-1 receptor je kod čoveka kodiran {{Gene|SIGMAR1}} [[gen]]om.<ref name="pmid8954936">{{cite journal | author = Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V | title = Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1) | journal = Biochem. Biophys. Res. Commun. | volume = 229 | issue = 2 | pages = 553–8 | year = 1996 | month = December | pmid = 8954936 | doi = 10.1006/bbrc.1996.1842 | url = | issn = }}</ref><ref name="pmid9453537">{{cite journal | author = Prasad PD, Li HW, Fei YJ, Ganapathy ME, Fujita T, Plumley LH, Yang-Feng TL, Leibach FH, Ganapathy V | title = Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene | journal = J. Neurochem. | volume = 70 | issue = 2 | pages = 443–51 | year = 1998 | month = February | pmid = 9453537 | doi = 10.1046/j.1471-4159.1998.70020443.x| url = | issn = }}</ref> |
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Sigma-1 receptor je [[Transmembranski receptor|transmembranski protein]] koji je izražen u mnogim tipovima tkiva. On je posebno koncentrovan u pojedinim regionima [[centralni nervni sistem|centralnog nervnog sistema]].<ref name="pmid2845055">{{cite journal | author = Weissman AD, Su TP, Hedreen JC, London ED | title = Sigma receptors in post-mortem human brains | journal = J. Pharmacol. Exp. Ther. | volume = 247 | issue = 1 | pages = 29–33 | year = 1988 | pmid = 2845055 | doi = | issn = }}</ref> Za njega se smatra da učestvuje u velikom broju sistema, što obuhvata kardiovaskularne funkcije, [[šizofrenija|šizofreniju]], [[klinička depresija|kliničku depresiju]], efekte zloupotrebe [[kokain]]a, i rak.<ref name="pmid15197533">{{cite journal | author = Guitart X, Codony X, Monroy X | title = Sigma receptors: biology and therapeutic potential | journal = Psychopharmacology (Berl.) | volume = 174 | issue = 3 | pages = 301–19 | year = 2004 | pmid = 15197533 | doi = 10.1007/s00213-004-1920-9 }}</ref><ref name="pmid15764734">{{cite journal | author = Zhang H, Cuevas J | title = sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons | journal = J. Pharmacol. Exp. Ther. | volume = 313 | issue = 3 | pages = 1387–96 | year = 2005 | pmid = 15764734 | doi = 10.1124/jpet.105.084152 }}</ref> Dostupne se detaljne informacije o afinitetu vezivanja stotina sintetičkih jedinjenja za sigma-1 receptor. |
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==Literatura== |
==Literatura== |
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Верзија на датум 26. април 2011. у 23:39
| Sigma-1 receptor 1 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | SIGMAR1; SRBP; OPRS1; FLJ25585; MGC3851 | ||||||||||
| Vanjski ID | OMIM: 601978 MGI: 1195268 HomoloGene: 39965 GeneCards: SIGMAR1 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 10280 | 18391 | |||||||||
| Ensembl | ENSG00000147955 | ENSMUSG00000036078 | |||||||||
| UniProt | Q99720 | O55242 | |||||||||
| RefSeq (mRNA) | NM_005866 | NM_011014 | |||||||||
| RefSeq (protein) | NP_005857 | NP_035144 | |||||||||
| Lokacija (UCSC) |
Chr 9: 34.62 - 34.63 Mb |
Chr 4: 41.69 - 41.69 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Sigma-1 receptor (σ1R) je šaperonski protein na endoplazmatičnom retikulumu (ER) koji moduliše kalcijumsku signalizaciju putem IP3 receptora.[1] Sigma-1 receptor je kod čoveka kodiran SIGMAR1 genom.[2][3]
Sigma-1 receptor je transmembranski protein koji je izražen u mnogim tipovima tkiva. On je posebno koncentrovan u pojedinim regionima centralnog nervnog sistema.[4] Za njega se smatra da učestvuje u velikom broju sistema, što obuhvata kardiovaskularne funkcije, šizofreniju, kliničku depresiju, efekte zloupotrebe kokaina, i rak.[5][6] Dostupne se detaljne informacije o afinitetu vezivanja stotina sintetičkih jedinjenja za sigma-1 receptor.
Literatura
- ^ Hayashi T, Su TP (2007). „Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival.”. Cell. 131 (3): 596—610. PMID 17981125. doi:10.1016/j.cell.2007.08.036.
- ^ Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V (1996). „Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)”. Biochem. Biophys. Res. Commun. 229 (2): 553—8. PMID 8954936. doi:10.1006/bbrc.1996.1842. Непознати параметар
|month=игнорисан (помоћ) - ^ Prasad PD, Li HW, Fei YJ, Ganapathy ME, Fujita T, Plumley LH, Yang-Feng TL, Leibach FH, Ganapathy V (1998). „Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene”. J. Neurochem. 70 (2): 443—51. PMID 9453537. doi:10.1046/j.1471-4159.1998.70020443.x. Непознати параметар
|month=игнорисан (помоћ) - ^ Weissman AD, Su TP, Hedreen JC, London ED (1988). „Sigma receptors in post-mortem human brains”. J. Pharmacol. Exp. Ther. 247 (1): 29—33. PMID 2845055.
- ^ Guitart X, Codony X, Monroy X (2004). „Sigma receptors: biology and therapeutic potential”. Psychopharmacology (Berl.). 174 (3): 301—19. PMID 15197533. doi:10.1007/s00213-004-1920-9.
- ^ Zhang H, Cuevas J (2005). „sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons”. J. Pharmacol. Exp. Ther. 313 (3): 1387—96. PMID 15764734. doi:10.1124/jpet.105.084152.