Kanabinoidni receptor tip 1 — разлика између измена

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== Reference ==
== Reference ==
{{reflist|2}}
{{reflist|2}}

== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
* {{Cite pmid|17678969}}
* {{Cite pmid|1718258}}
* {{cite journal | author=Hoehe MR, Caenazzo L, Martinez MM, ''et al.'' |title=Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15 |journal=New Biol. |volume=3 |issue= 9 |pages= 880–5 |year= 1991 |pmid= 1931832 |doi= }}
* {{cite journal | author=Matsuda LA, Lolait SJ, Brownstein MJ, ''et al.'' |title=Structure of a cannabinoid receptor and functional expression of the cloned cDNA |journal=Nature |volume=346 |issue= 6284 |pages= 561–4 |year= 1990 |pmid= 2165569 |doi= 10.1038/346561a0 |bibcode = 1990Natur.346..561M }}
* {{cite journal | author=Gérard C, Mollereau C, Vassart G, Parmentier M |title=Nucleotide sequence of a human cannabinoid receptor cDNA |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7142 |year= 1991 |pmid= 2263478 |doi=10.1093/nar/18.23.7142 | pmc=332788 }}
* {{cite journal | author=Shire D, Carillon C, Kaghad M, ''et al.'' |title=An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3726–31 |year= 1995 |pmid= 7876112 |doi=10.1074/jbc.270.8.3726 }}
* {{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
* {{cite journal | author=Kenney SP, Kekuda R, Prasad PD, ''et al.'' |title=Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta |journal=Am. J. Obstet. Gynecol. |volume=181 |issue= 2 |pages= 491–7 |year= 1999 |pmid= 10454705 |doi=10.1016/S0002-9378(99)70583-1 }}
* {{cite journal | author=Porcella A, Maxia C, Gessa GL, Pani L |title=The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein |journal=Eur. J. Neurosci. |volume=12 |issue= 3 |pages= 1123–7 |year= 2000 |pmid= 10762343 |doi=10.1046/j.1460-9568.2000.01027.x }}
* {{cite journal | author=Mukhopadhyay S, Howlett AC |title=CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 499–505 |year= 2001 |pmid= 11168387 |doi=10.1046/j.1432-1327.2001.01810.x }}
* {{cite journal | author=Murphy WJ, Eizirik E, Johnson WE, ''et al.'' |title=Molecular phylogenetics and the origins of placental mammals |journal=Nature |volume=409 |issue= 6820 |pages= 614–8 |year= 2001 |pmid= 11214319 |doi= 10.1038/35054550 }}
* {{cite journal | author=Nong L, Newton C, Friedman H, Klein TW |title=CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types |journal=Adv. Exp. Med. Biol. |volume=493 |issue= |pages= 229–33 |year= 2002 |pmid= 11727770 |doi=10.1007/0-306-47611-8_27 | series=Advances in Experimental Medicine and Biology | isbn=0-306-46466-7 }}
* {{cite journal | author=Leroy S, Griffon N, Bourdel MC, ''et al.'' |title=Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1 |journal=Am. J. Med. Genet. |volume=105 |issue= 8 |pages= 749–52 |year= 2002 |pmid= 11803524 |doi=10.1002/ajmg.10038 }}
* {{cite journal | author=Schmidt LG, Samochowiec J, Finckh U, ''et al.'' |title=Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence |journal=Drug and alcohol dependence |volume=65 |issue= 3 |pages= 221–4 |year= 2002 |pmid= 11841893 |doi=10.1016/S0376-8716(01)00164-8 }}
* {{cite journal | author=Lastres-Becker I, Cebeira M, de Ceballos ML, ''et al.'' |title=Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets |journal=Eur. J. Neurosci. |volume=14 |issue= 11 |pages= 1827–32 |year= 2002 |pmid= 11860478 |doi=10.1046/j.0953-816x.2001.01812.x }}
* {{cite journal | author=Petrelli A, Gilestro GF, Lanzardo S, ''et al.'' |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met |journal=Nature |volume=416 |issue= 6877 |pages= 187–90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a }}
* {{cite journal | author=Huang SM, Bisogno T, Trevisani M, ''et al.'' |title=An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8400–5 |year= 2002 |pmid= 12060783 |doi= 10.1073/pnas.122196999 | pmc=123079 |bibcode = 2002PNAS...99.8400H }}
* {{cite journal | author=Ujike H, Takaki M, Nakata K, ''et al.'' |title=CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 515–8 |year= 2002 |pmid= 12082570 |doi= 10.1038/sj.mp.4001029 }}
* {{cite journal | author=Ho BY, Current L, Drewett JG |title=Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16) |journal=FEBS Lett. |volume=522 |issue= 1–3 |pages= 130–4 |year= 2002 |pmid= 12095632 |doi=10.1016/S0014-5793(02)02917-4 }}
* {{cite journal | author=Matias I, Pochard P, Orlando P, ''et al.'' |title=Presence and regulation of the endocannabinoid system in human dendritic cells |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3771–8 |year= 2002 |pmid= 12153574 |doi=10.1046/j.1432-1033.2002.03078.x }}
}}
{{refend}}


== Spoljašnje veze ==
== Spoljašnje veze ==

Верзија на датум 21. јул 2012. у 10:26

Kanabinoidni receptor 1
Prikaz CNR1 iz PDB 1LVQ​
Dostupne strukture
1LVQ​, 1LVR​, 2B0Y​, 2KOE​
Identifikatori
Simboli CNR1; CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Vanjski ID OMIM: 114610 MGI: 104615 HomoloGene: 7273 IUPHAR: CB1 GeneCards: CNR1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1268 12801
Ensembl ENSG00000118432 ENSMUSG00000044288
UniProt P21554 P47746
RefSeq (mRNA) NM_001160226.1 NM_007726.3
RefSeq (protein) NP_001153698.1 NP_031752.1
Lokacija (UCSC) Chr 6:
88.85 - 88.88 Mb		 Chr 4:
34.01 - 34.04 Mb
PubMed pretraga [1] [2]

Kanabinoidni receptor tip 1 (CB1) je G protein spregnuti kanabinoidni receptor. CB1 je prvenstveno lociran u mozgu. On se aktivira endokanabinoidnim neurotransmiterima anandamidom i 2-arahidonoil gliceridom (2-AG); biljnim kanabinoidima, kao što je THC, aktivni sastojak psihoaktivnog leka kanabisa; i sintetičkim analozima THC, poput dronabinola.

Reference

Literatura

  • PMID 17678969 (PMID 17678969)
    Референца ће бити завршена аутоматски за неколико минута.

Прескочи ред или прошири ручно

  • PMID 1718258 (PMID 1718258)
    Референца ће бити завршена аутоматски за неколико минута.

Прескочи ред или прошири ручно

  • Hoehe MR, Caenazzo L, Martinez MM; et al. (1991). „Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15”. New Biol. 3 (9): 880—5. PMID 1931832. 
  • Matsuda LA, Lolait SJ, Brownstein MJ; et al. (1990). „Structure of a cannabinoid receptor and functional expression of the cloned cDNA”. Nature. 346 (6284): 561—4. Bibcode:1990Natur.346..561M. PMID 2165569. doi:10.1038/346561a0. 
  • Gérard C, Mollereau C, Vassart G, Parmentier M (1991). „Nucleotide sequence of a human cannabinoid receptor cDNA”. Nucleic Acids Res. 18 (23): 7142. PMC 332788 Слободан приступ. PMID 2263478. doi:10.1093/nar/18.23.7142. 
  • Shire D, Carillon C, Kaghad M; et al. (1995). „An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing”. J. Biol. Chem. 270 (8): 3726—31. PMID 7876112. doi:10.1074/jbc.270.8.3726. 
  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • Kenney SP, Kekuda R, Prasad PD; et al. (1999). „Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta”. Am. J. Obstet. Gynecol. 181 (2): 491—7. PMID 10454705. doi:10.1016/S0002-9378(99)70583-1. 
  • Porcella A, Maxia C, Gessa GL, Pani L (2000). „The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein”. Eur. J. Neurosci. 12 (3): 1123—7. PMID 10762343. doi:10.1046/j.1460-9568.2000.01027.x. 
  • Mukhopadhyay S, Howlett AC (2001). „CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains”. Eur. J. Biochem. 268 (3): 499—505. PMID 11168387. doi:10.1046/j.1432-1327.2001.01810.x. 
  • Murphy WJ, Eizirik E, Johnson WE; et al. (2001). „Molecular phylogenetics and the origins of placental mammals”. Nature. 409 (6820): 614—8. PMID 11214319. doi:10.1038/35054550. 
  • Nong L, Newton C, Friedman H, Klein TW (2002). „CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types”. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 493: 229—33. ISBN 0-306-46466-7. PMID 11727770. doi:10.1007/0-306-47611-8_27. 
  • Leroy S, Griffon N, Bourdel MC; et al. (2002). „Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1”. Am. J. Med. Genet. 105 (8): 749—52. PMID 11803524. doi:10.1002/ajmg.10038. 
  • Schmidt LG, Samochowiec J, Finckh U; et al. (2002). „Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence”. Drug and alcohol dependence. 65 (3): 221—4. PMID 11841893. doi:10.1016/S0376-8716(01)00164-8. 
  • Lastres-Becker I, Cebeira M, de Ceballos ML; et al. (2002). „Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets”. Eur. J. Neurosci. 14 (11): 1827—32. PMID 11860478. doi:10.1046/j.0953-816x.2001.01812.x. 
  • Petrelli A, Gilestro GF, Lanzardo S; et al. (2002). „The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met”. Nature. 416 (6877): 187—90. PMID 11894096. doi:10.1038/416187a. 
  • Huang SM, Bisogno T, Trevisani M; et al. (2002). „An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors”. Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8400—5. Bibcode:2002PNAS...99.8400H. PMC 123079 Слободан приступ. PMID 12060783. doi:10.1073/pnas.122196999. 
  • Ujike H, Takaki M, Nakata K; et al. (2002). „CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia”. Mol. Psychiatry. 7 (5): 515—8. PMID 12082570. doi:10.1038/sj.mp.4001029. 
  • Ho BY, Current L, Drewett JG (2002). „Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)”. FEBS Lett. 522 (1–3): 130—4. PMID 12095632. doi:10.1016/S0014-5793(02)02917-4. 
  • Matias I, Pochard P, Orlando P; et al. (2002). „Presence and regulation of the endocannabinoid system in human dendritic cells”. Eur. J. Biochem. 269 (15): 3771—8. PMID 12153574. doi:10.1046/j.1432-1033.2002.03078.x. 

Spoljašnje veze

Преузето из „https://sr.wikipedia.org/w/index.php?title=Kanabinoidni_receptor_tip_1&oldid=5746423”