Cistinilna aminopeptidaza
| Cistinilna aminopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.3 | ||||||||
| CAS broj | 9031-41-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Cistinilna aminopeptidaza (EC 3.4.11.3, cistil-aminopeptidaza, oksitocinaza, cistinska aminopeptidaza, L-cistinska aminopeptidaza, oksitocinska peptidaza, vazopresinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalnih aminokiselina, Cys-Xaa-, gde je polovina cistinskog ostataka deo disulfidne petlje, posebno u oksitocinu ili vazopresinu. Brihine hidrolize aminoacil arilamida su veće od cistinil derivata.
Ovaj cinkov sijaloglikoprotein pripada peptidaznoj familiji M1 (membranskoj alanil aminopeptidaznoj familiji).
Reference[uredi | uredi izvor]
- ^ Sjöholm, I. (1967). „Biochemical studies on oxytocin and oxytocinase”. Acta Pharm. Suec. 4: 81—96. PMID 6041057.
- ^ Sjöholm, I. & Yman, L. (1967). „Degradation of oxytocin, lysine vasopressin, angiotensin II, and angiotensin II amide by oxytocinase (cystine aminopeptidase)”. Acta Pharm. Suec. 4: 65—76. PMID 4292447.
- ^ Yman, L. (1970). „Studies on human serum aminopeptidase. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum”. Acta Pharm. Suec. 7: 75—86. PMID 5421622.
- ^ Sakura, H., Lin, T.Y., Doi, M., Mizutani, S. and Kawashima, Y. (1981). „Purification and properties of oxytocinase, a metalloenzyme”. Biochem. Int. 2: 173—179.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[uredi | uredi izvor]
- Cystinyl+aminopeptidase na US National Library of Medicine Medical Subject Headings (MeSH)
