GNB1

Vezujući protein guaninskog nukleotida, podjedinica beta-1
PDB prikaz baziran na 1a0r​.
Dostupne strukture
2QNS​, 3KJ5​
Identifikatori
Simbol	GNB1
Vanjski ID	OMIM: 139380 MGI: 95781 HomoloGene: 55532
Ontologija gena Molekularna funkcija • vezivanje G-protein spregnutog receptora • aktivnost GTPaza • aktivnost prenosa signala • GTP vezivanje Celularna komponenta • fotoreceptorski spoljašnji segment • intracelularni • membranska frakcija • heterotrimerni G-proteinski kompleks • ćelijska membrana Biološki proces • metabolički proces energijske rezerve • GTP katabolički proces • prenos signala • signalni put adenilat ciklazom aktiviranog dopaminskog receptora • signalni put fosfolipazom C aktivating G protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	n/a	14688
Ensembl	ENSG00000078369	ENSMUSG00000029064
UniProt	P62873	P62874
RefSeq (mRNA)	NM_002074.3	NM_001160016.1
RefSeq (protein)	NP_002065.1	NP_001153488.1
Lokacija (UCSC)	Chr 1: 1.72 - 1.82 Mb	Chr 4: 154.87 - 154.93 Mb
PubMed pretraga	n/a	[1]

Vezujući protein guaninskog nukleotida G(I)/G(S)/G(T) podjedinica beta-1 je protein koji je kod ljudi kodiran GNB1 genom.

Heterotrimerni vezujući protein guaninskog nukleotida (G proteina), koji integrišu signale između receptora i efektorskih proteina, se sastoje od alfa, beta, i gama podjedinice. Te podjedinice su kodirane familijama srodnih gena. Ovaj gen kodira beta podjedinicu, koja je regulator alfa podjedinica, kao i pojedinih receptora i efektora. Ovaj gen koristi alternativne signale poliadenilacije.

Interakcije

GNB1 formira interakcije sa GNG4.

Literatura

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• De Waard M; Liu H; Walker D; et al. (1997). „Direct binding of G-protein betagamma complex to voltage-dependent calcium channels”. Nature. 385 (6615): 446—50. PMID 9009193. doi:10.1038/385446a0. 
• Huang CL, Jan YN, Jan LY (1997). „Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels”. FEBS Lett. 405 (3): 291—8. PMID 9108307. doi:10.1016/S0014-5793(97)00197-X. 
• Yu W; Andersson B; Worley KC; et al. (1997). „Large-scale concatenation cDNA sequencing”. Genome Res. 7 (4): 353—8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353. 
• Qin N; Platano D; Olcese R; et al. (1997). „Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors”. Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866—71. PMC 23172 . PMID 9238069. doi:10.1073/pnas.94.16.8866. 
• Nishida K, Kaziro Y, Satoh T (1999). „Association of the proto-oncogene product dbl with G protein betagamma subunits”. FEBS Lett. 459 (2): 186—90. PMID 10518015. doi:10.1016/S0014-5793(99)01244-2. 
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• Carman CV; Barak LS; Chen C; et al. (2000). „Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2”. J. Biol. Chem. 275 (14): 10443—52. PMID 10744734. doi:10.1074/jbc.275.14.10443.