Karboksipeptidaza u
| Karboksipeptidaza u | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.17.20 | ||||||||
| CAS broj | 156621-18-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Karboksipeptidaza u (EC 3.4.17.20, argininska karboksipeptidaza, karboksipeptidaza R, plazmatična karboksipeptidaza B, trombinom aktivirani fibrinolizni inhibitor) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalnog Arg i Lys sa polipeptida
Pro-karboksipeptidaza U se u (ljudskoj) plazmi aktivira trombinom ili plazminom tokom zgrušavanja, čime se formira nestabilna karboksipeptidaza U.
Reference[уреди | уреди извор]
- ^ Eaton, D.L., Malloy, B.E., Tsai, S.P., Henzel, W. and Drayna, D. (1991). „Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma”. J. Biol. Chem. 266: 21833—21838. PMID 1939207.
- ^ Shinohara, T., Sakurada, C., Suzuki, T., Takeuchi, O., Campbell, W., Ikeda, S., Okada, N. and Okada, H. (1994). „Pro-carboxypeptidase R cleaves bradykinin following activation”. Int. Arch. Allergy Immunol. 103: 400—404. PMID 8130654.
- ^ Wang, W., Hendriks, D.F. and Scharpé, S. (1994). „Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen”. J. Biol. Chem. 269: 15937—15944. PMID 8195249.
- ^ Tan, A.K. & Eaton, D.L. (1995). „Activation and characterization of procarboxypeptidase B from human plasma”. Biochemistry. 34: 5811—5816. PMID 7727441.
- ^ Broze, G.J., Jr. & Higuchi, D.A. (1996). „Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase U and the premature lysis of clots from hemophilic plasma”. Blood. 88: 3815—3823. PMID 8916945.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Carboxypeptidase+U на US National Library of Medicine Medical Subject Headings (MeSH)
