D-aminokiselina transaminaza

Из Википедије, слободне енциклопедије
D-aminokiselina transaminaza
Identifikatori
EC broj 2.6.1.21
CAS broj 37277-85-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

D-aminokiselina transaminaza (EC 2.6.1.21, D-aspartatna transaminaza, D-alaninska aminotransferaza, D-aspartinska aminotransferaza, D-alanin-D-glutamatna transaminaza, D-alaninska transaminaza, D-aminokiselinska aminotransferaza) je enzim sa sistematskim imenom D-alanin:2-oksoglutarat aminotransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-alanin + 2-oksoglutarat \rightleftharpoons piruvat + D-glutamat

Ovaj enzim je piridoksal-fosfatni protein. Enzim iz termofilnih Bacillus vrsta deluje na mnoge D-aminokiseline. D-alanin i D-2-aminobutirat su najbolji amino donori.

Reference[уреди]

  1. Thorne, C.B., Gómez, C.G. and Housewright, R.D. (1955). „Transamination of D-amino acids by Bacillus subtilis“. J. Bacteriol. 69: 357-362. PMID 14367287. 
  2. Thorne, C.B. and Molnar, D.M. (1955). „D-Amino acid transamination in Bacillus anthracis“. J. Bacteriol. 70: 420-426. PMID 13263311. 
  3. Martinez-Carrion, M. and Jenkins, W.T. (1965). „D-Alanine-D-glutamate transaminase. I. Purification and characterization“. J. Biol. Chem. 240: 3538-3546. PMID 4953710. 
  4. Ozawa, T., Fukuda, M. and Sasaoka, K. (1973). „Occurrence of D-amino acid aminotransferase in pea seedlings“. Biochem. Biophys. Res. Commun. 52: 998-1002. PMID 4710577. 
  5. Yonaha, K., Misono, H., Yamamoto, T. and Soda, K. (1975). „D-Amino acid aminotransferase of Bacillus sphaericus. Enzymologic and spectrometric properties“. J. Biol. Chem. 250: 6983-6989. PMID 1158891. 
  6. Tanizawa, K., Masu, Y., Asano, S., Tanaka, H. and Soda, K. (1989). „Thermostable D-amino acid aminotransferase from a thermophilic Bacillus species. Purification, characterization, and active site sequence determination“. J. Biol. Chem. 264: 2445-2449. PMID 2914916. 
  7. Fotheringham, I.G., Bledig, S.A. and Taylor, P.P. (1998). „Characterization of the genes encoding D-amino acid transaminase and glutamate racemase, two D-glutamate biosynthetic enzymes of Bacillus sphaericus ATCC 10208“. J. Bacteriol. 180: 4319-4323. PMID 9696787. 
  8. van Ophem, P.W., Erickson, S.D., Martinez del Pozo, A., Haller, I., Chait, B.T., Yoshimura, T., Soda, K., Ringe, D., Petsko, G. and Manning, J.M. (1998). „Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation“. Biochemistry 37: 2879-2888. PMID 9485439. 
  9. Sugio, S., Petsko, G.A., Manning, J.M., Soda, K. and Ringe, D. (1995). „Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity“. Biochemistry 34: 9661-9669. PMID 7626635. 

Literatura[уреди]

Spoljašnje veze[уреди]