Deacetoksicefalosporin-C sintaza
| Deacetoksicefalosporin-C sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.20.1 | ||||||||
| CAS broj | 85746-10-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Deacetoksicefalosporin-C sintaza (EC 1.14.20.1, DAOCS, penicilinska N ekspandaza, DAOC sintaza) je enzim sa sistematskim imenom penicilin-N,2-oksoglutarat:kiseonik oksidoreduktaza (ekspanzija prstena).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim učestvuje u biosintezi penicilina.
Reference[уреди | уреди извор]
- ^ Cantwell, C., Beckmann, R., Whiteman, P., Queener, S.W. and Abraham, E.P. (1992). „Isolation of deacetoxycephalosporin-c from fermentation broths of Penicillium chrysogenum transformants - construction of a new fungal biosynthetic-pathway”. Proc. R. Soc. Lond. B Biol. Sci. 248: 283—289. PMID 1354366.
- ^ Lee, H.J., Lloyd, M.D., Harlos, K., Clifton, I.J., Baldwin, J.E. and Schofield, C.J. (2001). „Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)”. J. Mol. Biol. 308: 937—948. PMID 11352583.
- ^ Yeh, W.K., Ghag, S.K. and Queener, S.W. (1992). „Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3′-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering”. Ann. N.Y. Acad. Sci. 672: 396—408.
- ^ Valegaard, K., van Scheltinga, A.C.T., Lloyd, M.D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H.-J., Baldwin, J.E., Schofield, C.J., Hajdu, J. and Andersson, I. (1998). „Structure of a cephalosporin synthase”. Nature. 394: 805—809. PMID 9723623.
- ^ Dotzlaf, J.E. & Yeh, W.K. (1989). „Purification and properties of deacetoxycephalosporin C synthase from recombinant Escherichia coli and its comparison with the native enzyme purified from Streptomyces clavuligerus”. J. Biol. Chem. 264: 10219—10227. PMID 2656705.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Deacetoxycephalosporin-C+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
