GDP-manozna 4,6-dehidrataza
| GDP-manozna 4,6-dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.47 | ||||||||
| CAS broj | 37211-59-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GDP-manozna 4,6-dehidrataza (EC 4.2.1.47, guanozin 5'-difosfat-D-manoza oksidoreduktaza, guanozin difosfomanoza oksidoreduktaza, guanozin difosfomanoza 4,6-dehidrataza, GDP-D-manoza dehidrataza, GDP-D-manoza 4,6-dehidrataza, Gmd, GDP-manoza 4,6-hidrolijaza) je enzim sa sistematskim imenom GDP-manoza 4,6-hidrolijaza (formira GDP-4-dehidro-6-dezoksi-D-manoza).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-manoza GDP-4-dehidro-6-dezoksi-D-manoza + H2O
Bakterijski enzim funkcioniše u prisustvu NAD+.
Reference[уреди | уреди извор]
- ^ Elbein, A.D. & Heath, E.C. (1965). „The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. II. Guanosine diphosphate 4-keto-6-deoxy-D-mannose, an intermediate in the biosynthesis of guanosine diphosphate colitose”. J. Biol. Chem. 240: 1926—1931. PMID 14299611.
- ^ Liao, T.-H. & Barber, G.A. (1972). „Purification of guanosine 5′-diphosphate D-mannose oxidoreductase from Phaseolus vulgaris”. Biochim. Biophys. Acta. 276: 85—93. PMID 5047712.
- ^ Melo, A., Elliott, H. and Glaser, L. (1968). „The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase”. J. Biol. Chem. 243: 1467—1474. PMID 4869560.
- ^ Sullivan, F.X., Kumar, R., Kriz, R., Stahl, M., Xu, G.Y., Rouse, J., Chang, X.J., Boodhoo, A., Potvin, B. and Cumming, D.A. (1988). „Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro”. J. Biol. Chem. 273: 8193—8202. PMID 9525924.
- ^ Kneidinger, B., Graninger, M., Adam, G., Puchberger, M., Kosma, P., Zayni, S. and Messner, P. (2001). „Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T”. J. Biol. Chem. 276: 5577—5583. PMID 11096116.
- ^ Mulichak, A.M., Bonin, C.P., Reiter, W.D. and Garavito, R.M. (2000). „Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis thaliana: implications for ligand binding and specificity”. Biochemistry. 41: 15578—15589. PMID 12501186.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- GDP-mannose+4,6-dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)
