Inozitol-polifosfat multikinaza
| Inozitol-polifosfat multikinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.151 | ||||||||
| CAS broj | 9077-69-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Inozitol-polifosfat multikinaza (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinaza, IP3/IP4 dualno-specifična 6-/3-kinaza, IpmK, ArgRIII, AtIpk2alfa, AtIpk2beta, inozitol polifosfatna 6-/3-/5-kinaza) je enzim sa sistematskim imenom ATP:1D-mio-inozitol-1,4,5-trisfosfat 6-fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 ATP + 1D-mio-inozitol 1,4,5-trisfosfat 2 ADP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat (sveukupna reakcija)
- (1a) ATP + 1D-mio-inozitol 1,4,5-trisfosfat ADP + 1D-mio-inozitol 1,4,5,6-tetrakisfosfat
- (1b) ATP + 1D-mio-inozitol 1,4,5,6-tetrakisfosfat ADP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat
Ovaj enzim takođe fosforiliše Ins(1,4,5)P3 do Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 do Ins(1,3,4,5,6)P5, i Ins(1,3,4,5,6)P4 do Ins(PP)P4, nepoznatog izomera.
Reference[уреди | уреди извор]
- ^ Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. (1999). „Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases”. Curr. Biol. 9: 1323—1326. PMID 10574768.
- ^ Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D. (2000). „A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control”. Science. 287: 2026—2029. PMID 10720331.
- ^ Stevenson-Paulik, J., Odom, A.R. and York, J.D. (2002). „Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases”. J. Biol. Chem. 277: 42711—42718. PMID 12226109.
- ^ Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. (2005). „The pathway for the production of inositol hexakisphosphate in human cells”. J. Biol. Chem. 280: 1911—1920. PMID 15531582.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Inositol-polyphosphate+multikinase на US National Library of Medicine Medical Subject Headings (MeSH)
