Mn2+ zavisna ADP-ribozna/CDP-alkoholna difosfataza
| Mn2+ zavisna ADP-ribozna/CDP-alkoholna difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.53 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mn2+ zavisna ADP-ribozna/CDP-alkoholna difosfataza (EC 3.6.1.53, Mn2+-zavisna ADP-riboza/CDP-alkohol pirofosfataza, ADPRibaza-Mn) je enzim sa sistematskim imenom CDP-holin fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) CDP-holin + H2O CMP + fosfoholin
- (2) ADP-riboza + H2O AMP + D-riboza 5-fosfat
Za dejstvo ovog enzima je neophodan jon Mn2+.
Reference[уреди | уреди извор]
- ^ Canales, J., Pinto, R.M., Costas, M.J., Hernández, M.T., Miró, A., Bernet, D., Fernández, A. and Cameselle, J.C. (1995). „Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg2+-and/or Mn2+-dependent hydrolases acting on ADP-ribose”. Biochim. Biophys. Acta. 1246: 167—177. PMID 7819284.
- ^ Canales, J., Fernández, A., Ribeiro, J.M., Cabezas, A., Rodrigues, J.R., Cameselle, J.C. and Costas, M.J. (2008). „Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells”. Biochem. J. 413: 103—113. PMID 18352857.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Mn2+-dependent+ADP-ribose/CDP-alcohol+diphosphatase на US National Library of Medicine Medical Subject Headings (MeSH)
