RFC4
| Replikacioni faktor C (aktivator 1) 4, 37kDa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Идентификатори | |||||||||||
| Симболи | RFC4; A1; RFC37 | ||||||||||
| Вањски ИД | OMIM: 102577 MGI: 2146571 HomoloGene: 6288 GeneCards: RFC4 Gene | ||||||||||
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| Преглед РНК изражавања | |||||||||||
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| подаци | |||||||||||
| Ортолози | |||||||||||
| Врста | Човек | Миш | |||||||||
| Ентрез | 5984 | 106344 | |||||||||
| Eнсембл | ENSG00000163918 | ENSMUSG00000022881 | |||||||||
| UниПрот | P35249 | Q99J62 | |||||||||
| Реф. Секв. (иРНК) | NM_002916 | NM_145480 | |||||||||
| Реф. Секв. (протеин) | NP_002907 | NP_663455 | |||||||||
| Локација (УЦСЦ) |
Chr 3: 186.51 - 186.52 Mb |
Chr 16: 23.11 - 23.13 Mb | |||||||||
| ПубМед претрага | [1] | [2] | |||||||||
Репликациони фактор Ц, подјединица 4 је протеин који је код људи кодиран RFC4 геном.[1][2]
За елонгацију прајмираног ДНК шаблона ДНК полимеразе делта и ДНК полимеразе епсилон неопходни су помоћни протеини: пролиферативни ћелијски нуклеарни антиген (ПЦНА) и репликациони фактор Ц (RFC). RFC, такође познат као активатор 1, је протеински комплекс који се састоји од пет подјединица са 140, 40, 38, 37, и 36 kDа. Ова подјединица формира сржни комплекс са 36 и 40 kDа подјединицама. Комплекс манифестује ДНК зависно АТПазно дејство, које може да стимулише ПЦНА у ин витро системима. Познате су алтернативно сплајсоване трансцриптне варијанте које кодирају различите изоформе.[2]
Интеракције[уреди | уреди извор]
RFC4 формира интеракције са BRD4,[3] RFC2,[4][5] RFC3,[6][7] CHTF18,[8] PCNA[4][9] i RFC5.[4][5][6][10]
Референце[уреди | уреди извор]
- ^ Okumura K; Nogami M; Taguchi H; Dean FB; Chen M; Pan ZQ; Hurwitz J; Shiratori A; Murakami Y; Ozawa K; et al. (јул 1995). „Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23”. Genomics. 25 (1): 274—8. PMID 7774928. doi:10.1016/0888-7543(95)80135-9.
- ^ а б „Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa”.
- ^ Maruyama, Tetsuo; Farina Andrea; et al. (2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. United States. 22 (18): 6509—20. ISSN 0270-7306. PMC 135621
. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.
- ^ а б в Cai, J; Gibbs E; et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme”. J. Biol. Chem. UNITED STATES. 272 (30): 18974—81. ISSN 0021-9258. PMID 9228079. doi:10.1074/jbc.272.30.18974.
- ^ а б Cai, J; Yao N; et al. (1998). „ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (20): 11607—12. ISSN 0027-8424. PMC 21688 . PMID 9751713. doi:10.1073/pnas.95.20.11607.
- ^ а б Ellison, V; Stillman B (март 1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. UNITED STATES. 273 (10): 5979—87. ISSN 0021-9258. PMID 9488738. doi:10.1074/jbc.273.10.5979.
- ^ Uhlmann, F; Cai J; et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (13): 6521—6. ISSN 0027-8424. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
- ^ Bermudez, Vladimir P; Maniwa Yoshimasa; et al. (2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (18): 10237—42. ISSN 0027-8424. PMC 193545 . PMID 12930902. doi:10.1073/pnas.1434308100.
- ^ Ohta, Satoshi; Shiomi Yasushi; et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. United States. 277 (43): 40362—7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.
- ^ Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
Литература[уреди | уреди извор]
- Chen M, Pan ZQ, Hurwitz J (1992). „Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells”. Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5211—5. PMC 49261 . PMID 1351677. doi:10.1073/pnas.89.12.5211.
- Uhlmann F; Cai J; Flores-Rozas H; et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
- Cujec TP; Cho H; Maldonado E; et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817—23. PMC 232028 . PMID 9121429.
- Cai J; Gibbs E; Uhlmann F; et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme”. J. Biol. Chem. 272 (30): 18974—81. PMID 9228079. doi:10.1074/jbc.272.30.18974.
- Loor G; Zhang SJ; Zhang P; et al. (1998). „Identification of DNA replication and cell cycle proteins that interact with PCNA”. Nucleic Acids Res. 25 (24): 5041—6. PMC 147130 . PMID 9396813. doi:10.1093/nar/25.24.5041.
- Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979.
- Zhang G; Gibbs E; Kelman Z; et al. (1999). „Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869—74. PMC 26703 . PMID 10051561. doi:10.1073/pnas.96.5.1869.
- Uchiumi F, Watanabe M, Tanuma S (1999). „Characterization of telomere-binding activity of replication factor C large subunit p140”. Biochem. Biophys. Res. Commun. 258 (2): 482—9. PMID 10329413. doi:10.1006/bbrc.1999.0589.
- van der Kuip H; Carius B; Haque SJ; et al. (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365.
- Chaib H, Cockrell EK, Rubin MA, Macoska JA (2001). „Profiling and Verification of Gene Expression Patterns in Normal and Malignant Human Prostate Tissues by cDNA Microarray Analysis”. Neoplasia. 3 (1): 43—52. PMC 1505021 . PMID 11326315. doi:10.1038/sj/neo/7900126.
- Naiki T; Kondo T; Nakada D; et al. (2001). „Chl12 (Ctf18) Forms a Novel Replication Factor C-Related Complex and Functions Redundantly with Rad24 in the DNA Replication Checkpoint Pathway”. Mol. Cell. Biol. 21 (17): 5838—45. PMC 87303 . PMID 11486023. doi:10.1128/MCB.21.17.5838-5845.2001.
- Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). „Purification and characterization of human DNA damage checkpoint Rad complexes”. Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236—41. PMC 58713 . PMID 11572977. doi:10.1073/pnas.201373498.
- Griffith JD, Lindsey-Boltz LA, Sancar A (2002). „Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy”. J. Biol. Chem. 277 (18): 15233—6. PMID 11907025. doi:10.1074/jbc.C200129200.
- Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200.
- Ohta S; Shiomi Y; Sugimoto K; et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
- Maruyama T; Farina A; Dey A; et al. (2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 . PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Anderson LA, Perkins ND (2003). „Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C”. Mol. Cell. Biol. 23 (2): 721—32. PMC 151544 . PMID 12509469. doi:10.1128/MCB.23.2.721-732.2003.
- Nagata T; Takahashi Y; Ishii Y; et al. (2004). „Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array”. Int. J. Mol. Med. 11 (6): 713—21. PMID 12736711. doi:10.3892/ijmm.11.6.713.