Извор странице DPM3

{{Infobox_gene}}

'''Polipeptid dolihil-fosfat manoziltransferaze 3''', takođe poznat kao '''DPM3''', je ljudski [[gen]].<ref name="entrez">{{cite web | title = Entrez Gene: dolichyl-phosphate mannosyltransferase polypeptide 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54344}}</ref><ref name="pmid10835346">{{cite journal |vauthors=Maeda Y, Tanaka S, Hino J, Kangawa K, Kinoshita T | title = Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 | journal = EMBO J. | volume = 19 | issue = 11 | pages = 2475–82 |date=June 2000 | pmid = 10835346 | pmc = 212771 | doi = 10.1093/emboj/19.11.2475 }}</ref>

== Funkcija ==

Dolihol-fosfatna manoza (Dol-P-Man) služi kao donator manozilnih ostataka na lumenalnoj strani [[endoplasmic reticulum|endoplazmatskog retikuluma]] (ER). Nedostatak Dol-P-Man-a rezultira defektnom površinskom ekspresijom GPI-usidrenih proteina. Dol-P-Man se sintetiše iz [[GDP-mannose|GDP-manoze]] i [[dolichol-phosphate|dolihol-fosfata]] na citosolnoj strani ER pomoću enzima dolihil-fosfat manoziltransferaze. Protein koji je kodiran ovim genom je podjedinica dolihil-fosfat manoziltransferaze i deluje kao stabilizatorska podjedinica kompleksa dolihil-fosfat manoziltransferaze.<ref name="entrez"/>

== Klinički značaj ==

Mutacije ovog gena su povezane sa [[congenital disorder of glycosylation|urođenim poremećajem glikozilacije]] tipa 1O.<ref name="pmid19862844">{{cite journal | vauthors = Haeuptle MA, Hennet T | title = Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides | journal = Hum. Mutat. | volume = 30 | issue = 12 | pages = 1628–41 | date = December 2009 | pmid = 19862844 | doi = 10.1002/humu.21126 | s2cid = 46281092 | url = https://www.zora.uzh.ch/id/eprint/25758/4/Haeuptle_Hennet-HumMut_2009.pdf | access-date = 2019-12-11 | archive-date = 2021-05-18 | archive-url = https://web.archive.org/web/20210518201527/https://www.zora.uzh.ch/id/eprint/25758/4/Haeuptle_Hennet-HumMut_2009.pdf | url-status = dead }}</ref>

== Reference ==
{{reflist}}

== Literatura ==
{{Литература|30em}}
*{{cite journal  |vauthors=Maeda Y, Watanabe R, Harris CL |title=PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. |journal=EMBO J. |volume=20 |issue= 1–2 |pages= 250–61 |year= 2001 |pmid= 11226175 |doi= 10.1093/emboj/20.1.250 |pmc=140182|display-authors=etal}}
*{{cite journal  |vauthors=Ashida H, Maeda Y, Kinoshita T |title=DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 896–904 |year= 2006 |pmid= 16280320 |doi= 10.1074/jbc.M511311200 |doi-access= free }}
*{{cite journal  |vauthors=Maeda Y, Tanaka S, Hino J |title=Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2475–82 |year= 2000 |pmid= 10835346 |doi= 10.1093/emboj/19.11.2475 |pmc=212771|display-authors=etal}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  |vauthors=Manos EJ, Kim ML, Kassis J |title=Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. |journal=Oncogene |volume=20 |issue= 22 |pages= 2781–90 |year= 2001 |pmid= 11420690 |doi= 10.1038/sj.onc.1204379 |display-authors=etal|doi-access=free }}
*{{cite journal  |vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}
{{Литература крај}}

== Spoljašnje veze ==
* [https://www.ncbi.nlm.nih.gov/books/NBK1332/  GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]

{{Glycosyltransferases}}
{{Enzimi-lat}}
{{Authority control-lat}}

[[Category:EC 2.4.1]]