Извор странице FMO5

{{Infobox_gene}}
'''Dimetilanilin monooksigenaza (N-oksid-formirajuća) 5''' je [[enzim]] koji je kod ljudi kodiran ''FMO5'' [[gen]]om.<ref name="pmid8786146">{{cite journal |vauthors=McCombie RR, Dolphin CT, Povey S, Phillips IR, Shephard EA | title = Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q | journal = Genomics | volume = 34 | issue = 3 | pages = 426–9 |date= 1996 | pmid = 8786146 | pmc =  | doi = 10.1006/geno.1996.0308 }}</ref><ref name="pmid9119381">{{cite journal |vauthors=Gelb BD, Zhang J, Cotter PD, Gershin IF, Desnick RJ | title = Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21 | journal = Genomics | volume = 39 | issue = 3 | pages = 409–11 |date= 1997 | pmid = 9119381 | pmc =  | doi = 10.1006/geno.1996.4516 }}</ref><ref name="entrez"/>

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{{PBB_Summary
| section_title = 
| summary_text = Metabolička N-oksidacija amino-trimetilamina (TMA) iz hrane je posredovana [[monooksigenaza|monooksigenazom]] koja sadrži flavin. Ovaj gen ispoljava nasledni FMO3 polimorfizam kod ljudi koji rezultira u maloj potpopulaciji sa umanjenom TMA N-oksidacionom sposobnošću, posledica čega je sindrom zadaha ribe, [[trimetilaminurija]]. Tri forme ovog enzima, FMO1 u fetalnoj jetri, FMO2 u jetri odraslih osoba, i FMO3 su kodirani genima koji su grupisani u 1q23-q25 regionu. Monooksigenze koje sadrže [[flavin]] su [[Nikotinamid adenin dinukleotid fosfat|NADPH]] zavisni flavoenzimi koji katalizuju oksidaciju [[nukleofil]]nih heteroatomskih centera [[ksenobiotik]]a kao što su [[pesticid]]i i [[lek]]ovi.<ref name="entrez">{{cite web | title = Entrez Gene: FMO5 flavin containing monooxygenase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2330| accessdate = }}</ref>
}}

== Vidi još ==
* [[Dimetilanilin monooksigenaza (formiranje N-oksida)]]

==Reference==
{{reflist}}

==Literatura==
{{Литература | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  |vauthors=Hines RN, Cashman JR, Philpot RM |title=The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. |journal=Toxicol. Appl. Pharmacol. |volume=125 |issue= 1 |pages= 1–6 |year= 1994 |pmid= 8128486 |doi= 10.1006/taap.1994.1042 |display-authors=etal}}
*{{cite journal  |vauthors=Phillips IR, Dolphin CT, Clair P |title=The molecular biology of the flavin-containing monooxygenases of man. |journal=Chem. Biol. Interact. |volume=96 |issue= 1 |pages= 17–32 |year= 1995 |pmid= 7720101 |doi=10.1016/0009-2797(94)03580-2  |display-authors=etal}}
*{{cite journal  |vauthors=Overby LH, Buckpitt AR, Lawton MP |title=Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. |journal=Arch. Biochem. Biophys. |volume=317 |issue= 1 |pages= 275–84 |year= 1995 |pmid= 7872795 |doi=10.1006/abbi.1995.1163  |display-authors=etal}}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  |vauthors=Lawton MP, Cashman JR, Cresteil T |title=A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities |journal=Arch. Biochem. Biophys. |volume=308 |issue= 1 |pages= 254–7 |year= 1994 |pmid= 8311461 |doi=10.1006/abbi.1994.1035  |display-authors=etal}}
*{{cite journal  |vauthors=Overby LH, Carver GC, Philpot RM |title=Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans |journal=Chem. Biol. Interact. |volume=106 |issue= 1 |pages= 29–45 |year= 1997 |pmid= 9305407 |doi=10.1016/S0009-2797(97)00055-0  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  |vauthors=Chung WG, Park CS, Roh HK |title=Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450 |journal=Jpn. J. Pharmacol. |volume=84 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11128045 |doi=10.1254/jjp.84.213  |display-authors=etal}}
*{{cite journal  |vauthors=Janmohamed A, Dolphin CT, Phillips IR, Shephard EA |title=Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450 |journal=Biochem. Pharmacol. |volume=62 |issue= 6 |pages= 777–86 |year= 2001 |pmid= 11551524 |doi=10.1016/S0006-2952(01)00718-3  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Krause RJ, Lash LH, Elfarra AA |title=Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity |url=https://archive.org/details/sim_journal-of-pharmacology-and-experimental-therapeutics_2003-01_304_1/page/185 |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 185–91 |year= 2003 |pmid= 12490590 |doi= 10.1124/jpet.102.042911 }}
*{{cite journal  |vauthors=Furnes B, Feng J, Sommer SS, Schlenk D |title=Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans |journal=Drug Metab. Dispos. |volume=31 |issue= 2 |pages= 187–93 |year= 2003 |pmid= 12527699 |doi=10.1124/dmd.31.2.187  }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  |vauthors=Zhang J, Cashman JR |title=Quantitative analysis of FMO gene mRNA levels in human tissues |journal=Drug Metab. Dispos. |volume=34 |issue= 1 |pages= 19–26 |year= 2006 |pmid= 16183778 |doi= 10.1124/dmd.105.006171 }}
*{{cite journal  |vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
}}
{{Литература крај}}

{{Dioxygenases}}
{{Enzimi-lat}}

{{normativna kontrola}}

[[Категорија:Гени на хромозому 1]]