Извор странице Histaminski H1 receptor

{{DISPLAYTITLE:Histaminski H<sub>1</sub> receptor}}
{{PBB|geneid=3269}}
'''H<sub>1</sub> receptor''' je [[histaminski receptor]] iz familije [[Rodopsinu-slični receptori|rodopsinu sličnih]] [[G protein spregnuti receptor|G protein spregnutih receptora]]. Ovaj receptor, koji aktivira [[biogeni amin]] [[histamin]], je izražen širom tela, u [[Глатки мишић|glatkim mišićima]], vaskularnim [[endotel|endotelnim ćelijama]], u srcu, i u [[centralni nervni sistem|centralnom nervnom sistemu]]. H<sub>1</sub> receptor je spregnut sa intracelularnim [[G protein]]om (-{G<sub>q</sub>}-) koji aktivira signalni put [[Fosfolipaza C|fosfolipaze C]] i [[fosfatidilinozitol]]a (PIP2). [[Антихистаминик|Antihistamini]] koji deluju na ovaj receptor se koriste kao lekovi protiv alergije. Kristalna struktura receptora je određena.<ref>{{Cite journal  | author = Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata  | title = Structure of the human histamine H1 receptor complex with doxepin  | journal = Nature  | volume = 475  | issue = 7354  |year=2011| doi = 10.1038/nature10236  | pmid = 21697825 |pages=65–70 }}</ref>

== Reference ==
{{reflist|2}}

== Literatura ==
{{Литература | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  |vauthors=Mitsuchashi M, Payan DG |title=Molecular and cellular analysis of histamine H1 receptors on cultured smooth muscle cells. |journal=J. Cell. Biochem. |volume=40 |issue= 2 |year=1989|pmid= 2670975 |doi= 10.1002/jcb.240400207 |pages=183–92}}
*{{cite journal  |last=SS|first=Braman|title=Histamine receptors in the lung. |journal=N Engl Reg Allergy Proc |volume=8 |issue= 2 |year=1987|pmid= 2886904 |doi=10.2500/108854187778994446  |pages=116–20}}
*{{cite journal  |author1=Hill SJ |author2=Ganellin CR |author3=Timmerman H |author4=''et al.'' |title=International Union of Pharmacology. XIII. Classification of histamine receptors. |journal=Pharmacol. Rev. |volume=49 |issue= 3 |year=1997|pmid= 9311023 |doi=  |pages=253–78}}
*{{cite journal  |vauthors=Holden CA, Chan SC, Norris S, Hanifin JM |title=Histamine induced elevation of cyclic AMP phosphodiesterase activity in human monocytes. |journal=Agents Actions |volume=22 |issue= 1–2 |year=1988|pmid= 2891264 |doi=10.1007/BF01968814  |pages=36–42}}
*{{cite journal  |author1=Moguilevsky N |author2=Varsalona F |author3=Noyer M |author4=''et al.'' |title=Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene |journal=Eur. J. Biochem. |volume=224 |issue= 2 |year=1994|pmid= 7925364 |doi=10.1111/j.1432-1033.1994.00489.x  |pages=489–95}}
*{{cite journal  |author1=Fukui H |author2=Fujimoto K |author3=Mizuguchi H |author4=''et al.'' |title=Molecular cloning of the human histamine H1 receptor gene |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 2 |year=1994|pmid= 8003029 |doi= 10.1006/bbrc.1994.1786 |pages=894–901}}
*{{cite journal  |author1=Le Coniat M |author2=Traiffort E |author3=Ruat M |author4=''et al.'' |title=Chromosomal localization of the human histamine H1-receptor gene |url=https://archive.org/details/sim_human-genetics_1994-08_94_2/page/186 |journal=Hum. Genet. |volume=94 |issue= 2 |year=1994|pmid= 8045566 |doi=  |pages=186–8}}
*{{cite journal  |author1=De Backer MD |author2=Gommeren W |author3=Moereels H |author4=''et al.'' |title=Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 3 |year=1994|pmid= 8280179 |doi=10.1006/bbrc.1993.2662  |pages=1601–8}}
*{{cite journal  |vauthors=Hishinuma S, Young JM |title=Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation |journal=Br. J. Pharmacol. |volume=116 |issue= 6 |year=1996|pmid= 8590995 |doi=  | pmc=1909113  |pages=2715–23}}
*{{cite journal  |vauthors=Max SI, Chowdhury BA, Fraser CM |title=Sequence analysis of the 5'-untranslated region of the human H1 histamine receptor-encoding gene |url=https://archive.org/details/sim_gene_1996_171_2/page/309 |journal=Gene |volume=171 |issue= 2 |year=1996|pmid= 8666296 |doi=10.1016/0378-1119(96)00036-4  |pages=309–10}}
*{{cite journal  |author1=De Backer MD |author2=Loonen I |author3=Verhasselt P |author4=''et al.'' |title=Structure of the human histamine H1 receptor gene |journal=Biochem. J. |volume=335 |issue=  3|year=1998|pmid= 9794809 |doi=  | pmc=1219830  |pages=663–70}}
*{{cite journal  |author1=Horváth BV |author2=Szalai C |author3=Mándi Y |author4=''et al.'' |title=Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets |journal=Immunol. Lett. |volume=70 |issue= 2 |year=1999|pmid= 10569698 |doi=10.1016/S0165-2478(99)00126-1  |pages=95–9}}
*{{cite journal  |author1=Wang KY |author2=Arima N |author3=Higuchi S |author4=''et al.'' |title=Switch of histamine receptor expression from H2 to H1 during differentiation of monocytes into macrophages |journal=FEBS Lett. |volume=473 |issue= 3 |year=2000|pmid= 10818238 |doi=10.1016/S0014-5793(00)01560-X  |pages=345–8}}
*{{cite journal  |author1=Oda T |author2=Morikawa N |author3=Saito Y |author4=''et al.'' |title=Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes |journal=J. Biol. Chem. |volume=275 |issue= 47 |year=2001|pmid= 10973974 |doi= 10.1074/jbc.M006480200 |pages=36781–6}}
*{{cite journal  |vauthors=Brew OB, Sullivan MH |title=Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy |journal=Inflamm. Res. |volume=50 |issue= 9 |year=2002|pmid= 11603849 |doi=10.1007/PL00000269  |pages=449–52}}
*{{cite journal  |author1=Gutzmer R |author2=Langer K |author3=Lisewski M |author4=''et al.'' |title=Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells |url=https://archive.org/details/sim_journal-of-allergy-and-clinical-immunology_2002-03_109_3/page/524 |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 3 |year=2002|pmid= 11898002 |doi=10.1067/mai.2002.121944  |pages=524–31}}
*{{cite journal  |author1=Idzko M |author2=la Sala A |author3=Ferrari D |author4=''et al.'' |title=Expression and function of histamine receptors in human monocyte-derived dendritic cells |url=https://archive.org/details/sim_journal-of-allergy-and-clinical-immunology_2002-05_109_5/page/839 |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 5 |year=2002|pmid= 11994709 |doi=10.1067/mai.2002.124044  |pages=839–46}}
}}
{{Литература крај}}

== Vidi još ==
* [[Antihistaminik]] – antagonist H<sub>1</sub> receptora

== Spoljašnje veze ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2303 | title = Histamine Receptors: H<sub>1</sub> | accessdate =  | date =  | format =  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | language =  | archiveurl = https://web.archive.org/web/20160303192657/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2303 | archivedate = 03. 03. 2016 | quote =  | url-status =  }}
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{{G protein spregnuti receptori-lat}}
{{Histaminergici-lat}}

{{normativna kontrola}}

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