2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin

2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin
Nazivi
	IUPAC naziv 2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin
	Drugi nazivi PhIP
Identifikacija
CAS broj	105650-23-5 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	1476 ;
DrugBank	DB08398 =;
ECHA InfoCard	100.159.539
PubChem C ID	1530;
	SMILES n1cc(cc2c1nc(n2C)N)c3ccccc3; ; ; ; ; ;
Svojstva
Hemijska formula	C13H12N4
Molarna masa	224,27 g·mol−1
Agregatno stanje	bela čvrsta materija
Gustina	1,3 gcm−3
Tačka topljenja	300 °C (572 °F; 573 K)
Tačka ključanja	4.689 °C (8.472 °F; 4.962 K)
Rastvorljivost u vodi	407,1 mg/L
Opasnosti
Opasnost u toku rada	T
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

PhIP (2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin) jedan je od najzastupljenijih heterocikličnigh amina (HCA) u kuvanom mesu. PhIP se formira na visokim temperaturama reakcijom između kreatina ili kreatinina (prisutnog u mišićnom tkivu), aminokiselina, i šećera. PhIP formiranje se povećava sa povećanjem temperature i dužinom kuvanja, a takođe je zavisno od metoda kuvanja i tipa mesa. Smatra se da može da bude kancirogen.^[3]^[4]^[5]

Reference[uredi | uredi izvor]

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. (2011). Report on Carcinogens, 12th ed.. pp. 222.}-
^ -{International Agency for Research on Cancer (IARC) (1997) PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)(Group 2B). Summaries & Evaluations.
^ -{Cross, A., & Sinha, R. (2004) Meat-Related Mutagens/Carcinogens in the Etiology of Colorectal Cancer. Environmental and Molecular Mutagenesis. 44:45-55.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. (2011). Report on Carcinogens, 12th ed.. pp. 222.}-

[4] -{International Agency for Research on Cancer (IARC) (1997) PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)(Group 2B). Summaries & Evaluations.

[cross-5] -{Cross, A., & Sinha, R. (2004) Meat-Related Mutagens/Carcinogens in the Etiology of Colorectal Cancer. Environmental and Molecular Mutagenesis. 44:45-55.

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