3,3-Dimetil-1-butanol

3,3-Dimetil-1-butanol
Nazivi
	Preferisani IUPAC naziv 3,3-Dimetilbutan-1-ol
	Drugi nazivi 3,3-Dimetil-1-butanol
Identifikacija
CAS broj	624-95-3;
3D model (Jmol)	interaktivna slika;
ChemSpider	11732;
ECHA InfoCard	100.009.884
PubChem C ID	12233;
	SMILES CC(C)(C)CCO; ; ; ; ; ;
Svojstva
Hemijska formula	C6H14O
Molarna masa	102,18 g·mol−1
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

3,3-Dimetil-1-butanol (DMB) je strukturni analog holina.^[3]

Efekti[уреди | уреди извор]

DMB inhibira formiranje mikrobnog trimetilamina (TMA) kod miševa i ljudi, čime se redukuju nivoi trimetilamin N-oksida u plazmi (TMAO) nakon holinske ili karnitinske suplementacije.^[3] On konsekventno inhibira formiranje holinski pojačanih endogenih makrofagnih penastih ćelija i razviće ateroskleroznih povreda kod miševa bez promena nivoa circulišućeg holesterola.^[3]

Reference[уреди | уреди извор]

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ ^а ^б ^в Wang, Zeneng; Roberts, Adam B.; Buffa, Jennifer A.; Levison, Bruce S.; Zhu, Weifei; Org, Elin; Gu, Xiaodong; Huang, Ying; Zamanian-Daryoush, Maryam; Culley, Miranda K.; DiDonato, Anthony J.; Fu, Xiaoming; Hazen, Jennie E.; Krajcik, Daniel; DiDonato, Joseph A.; Lusis, Aldons J.; Hazen, Stanley L. (2015). „Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis”. Cell. 163 (7): 1585—1595. doi:10.1016/j.cell.2015.11.055.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[cell.2015.11.055-3] а ^б ^в Wang, Zeneng; Roberts, Adam B.; Buffa, Jennifer A.; Levison, Bruce S.; Zhu, Weifei; Org, Elin; Gu, Xiaodong; Huang, Ying; Zamanian-Daryoush, Maryam; Culley, Miranda K.; DiDonato, Anthony J.; Fu, Xiaoming; Hazen, Jennie E.; Krajcik, Daniel; DiDonato, Joseph A.; Lusis, Aldons J.; Hazen, Stanley L. (2015). „Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis”. Cell. 163 (7): 1585—1595. doi:10.1016/j.cell.2015.11.055.

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