7-hloro-L-triptofan oksidaza
| 7-hloro-L-triptofan oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.3.23 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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7-hloro-L-triptofan oksidaza (EC 1.4.3.23, RebO) je enzim sa sistematskim imenom 7-hloro-L-triptofan:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 7-hloro-L-triptofan + O2 2-imino-3-(7-hloroindol-3-il)propanoat +H2O2
Ovaj enzim sadrži nekovalentno vezani FAD. Ovaj enzim katalizuje prvi korak biosinteze rebekamicina, indolokarbazolnog alkaloida koji formira Actinobakterija Lechevalieria.
Reference[уреди | уреди извор]
- ^ Nishizawa, T., Aldrich, C.C. and Sherman, D.H. (2005). „Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243”. J. Bacteriol. 187: 2084—2092. PMID 15743957.
- ^ Howard-Jones, A.R. & Walsh, C.T. (2005). „Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD”. Biochemistry. 44: 15652—15663. PMID 16313168.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 7-chloro-L-tryptophan+oxidase на US National Library of Medicine Medical Subject Headings (MeSH)
