Defibrotid
| Klinički podaci | |
|---|---|
| Prodajno ime | Dasovas, Noravid, Prociclide |
| Drugs.com | Monografija |
| Način primene | Intramaskularno, oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 10-20 minuta |
| Identifikatori | |
| CAS broj | 83712-60-1  |
| ATC kod | B01AX01 (WHO) |
| DrugBank | DB04932 |
Defibrotid je natrimova so smeše jednolančanih oligodezoksiribonukleotida izvedenih iz DNK svinjske sluzokože ili goveđih pluća. Defibrotid ima antitrombotska, antiinflamatorna i antiishemijska svojstva (bez znatnih sistemskih antikoagulantskih efekata). On je u prodaji pod imenima: Dasovas (FM), Noravid, i Prociclide.[1][2][3][4][5][6][7][8]
Reference[уреди | уреди извор]
- ^ Noseda G, Fragiacomo C, Ferrari D: Pharmacokinetics of defibrotide in healthy volunteers. Haemostasis. 1986;16 Suppl 1:26-30. PMID 3754833
- ^ Palmer KJ, Goa KL: Defibrotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders. Drugs. 1993 Feb;45(2):259-94. PMID 7681375
- ^ Fisher J, Johnston AM, Holland TK, McCallum J, Pescador R, Mantovani M, Prino G: Pharmacokinetics, absorption, distribution and disposition of [125I]-defibrotide following intravenous or oral administration in the rat. Thromb Res. 1993 Apr 1;70(1):77-90. PMID 8511753
- ^ Koehl GE, Geissler EK, Iacobelli M, Frei C, Burger V, Haffner S, Holler E, Andreesen R, Schlitt HJ, Eissner G: Defibrotide: An Endothelium Protecting and Stabilizing Drug, has an Anti-Angiogenic Potential In Vitro and In Vivo. Cancer Biol Ther. 2007 May;6(5):686-90. Epub 2007 Feb 3. PMID 17495522
- ^ Kornblum N, Ayyanar K, Benimetskaya L, Richardson P, Iacobelli M, Stein CA: Defibrotide, a polydisperse mixture of single-stranded phosphodiester oligonucleotides with lifesaving activity in severe hepatic veno-occlusive disease: clinical outcomes and potential mechanisms of action. Oligonucleotides. 2006 Spring;16(1):105-14. PMID 16584299
- ^ Pescador R, Porta R, Ferro L: An integrated view of the activities of defibrotide. Semin Thromb Hemost. 1996;22 Suppl 1:71-5. PMID 8807733
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
Literatura[уреди | уреди извор]
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
