Jodid peroksidaza

Из Википедије, слободне енциклопедије
Jodid peroksidaza
Identifikatori
EC broj 1.11.1.8
CAS broj 9031-28-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Jodid peroksidaza (EC 1.11.1.8, tiroidna peroksidaza, jodotirozinska dejodaza, jodinaza, jodoperoksidaza (hem tip), jodidna peroksidaza-tirozinska jodinaza, jodotirozinska dejodinaza, monojodotirozinska dejodinaza, tiroperoksidaza, tirozinska jodinaza, TPO) je enzim sa sistematskim imenom jod:vodonik-peroksid oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) 2 jodid + H2O2 + 2 H+ \rightleftharpoons dijodin + 2H2O
(2) [tiroglobulin]-L-tirozin + jodid + H2O2 \rightleftharpoons [tiroglobulin]-3-jodo-L-tirozin + 2H2O
(3) [tiroglobulin]-3-jodo-L-tirozin + jodid + H2O2 \rightleftharpoons [tiroglobulin]-3,5-dijodo-L-tirozin + 2H2O
(4) 2 [tiroglobulin]-3,5-dijodo-L-tirozin + H2O2 \rightleftharpoons [tiroglobulin]-L-tiroksin + [tiroglobulin]-aminoakrilat + 2H2O
(5) [tiroglobulin]-3-jodo-L-tirozin + [tiroglobulin]-3,5-dijodo-L-tirozin + H2O2 \rightleftharpoons [tiroglobulin]-3,5,3'-trijodo-L-tironin + [tiroglobulin]-aminoakrilat + 2H2O

Tiroidna peroksidaza katalizuje biosintezu tiroidnih hormona L-tiroksina i trijodo-L-tironina.

Reference[уреди]

  1. ^ Cunningham, B.A. and Kirkwood, S. (1961). „Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system“. J. Biol. Chem. 236: 485-489. PMID 13718859. 
  2. ^ Hosoya, T., Kondo, Y. and Ui, N. (1962). „Peroxidase activity in thyroid gland and partial purification of the enzyme“. J. Biochem. (Tokyo) 52: 180-189. PMID 13964156. 
  3. ^ Coval, M.L. and Taurog, A. (1967). „Purification and iodinating activity of hog thyroid peroxidase“. J. Biol. Chem. 242: 5510-5523. PMID 12325367. 
  4. ^ Gavaret, J.M., Cahnmann, H.J. and Nunez, J. (1981). „Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction“. J. Biol. Chem. 256: 9167-9173. PMID 7021557. 
  5. ^ Ohtaki, S., Nakagawa, H., Nakamura, M. and Yamazaki, I. (1982). „One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase“. J. Biol. Chem. 257: 13398-13403. PMID 7142155. 
  6. ^ Magnusson, R.P., Taurog, A. and Dorris, M.L. (1984). „Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase“. J. Biol. Chem. 259: 197-205. PMID 6706930. 
  7. ^ Virion, A., Courtin, F., Deme, D., Michot, J.L., Kaniewski, J. and Pommier, J. (1985). „Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions“. Arch. Biochem. Biophys. 242: 41-47. PMID 2996435. 
  8. ^ Rawitch, A.B., Pollock, G., Yang, S.X. and Taurog, A. (1992). „Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase“. Arch. Biochem. Biophys. 297: 321-327. PMID 1497352. 
  9. ^ Sun, W. and Dunford, H.B. (1993). „Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine“. Biochemistry 32: 1324-1331. PMID 8448141. 
  10. ^ Taurog, A., Dorris, M.L. and Doerge, D.R. (1996). „Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase“. Arch. Biochem. Biophys. 330: 24-32. PMID 8651700. 
  11. ^ Ruf, J. and Carayon, P. (2006). „Structural and functional aspects of thyroid peroxidase“. Arch. Biochem. Biophys. 445: 269-277. PMID 16098474. 

Literatura[уреди]

Spoljašnje veze[уреди]