Molibdopterin sintaza sumportransferaza
| Molibdopterin sintaza sumportransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.1.11 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Molibdopterin sintaza sumportransferaza (EC 2.8.1.11, adenililtransferaza i sumportransferaza MOCS3, Cnx5 (gen), molibdopterin sintaza sumporilaza) je enzim sa sistematskim imenom persumporna L-cistein desumporaza:(molibdopterin-sintaza sumpor-nosilac protein)-Gly-Gly sumportransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- [molibdopterin-sintaza sumpor-nosilac protein]-Gly-Gly-AMP + [cistein desumporaza]-S-sulfanil-L-cistein AMP + [molibdopterin-sintaza sumpor-nosilac protein]-Gly-NH-CH2-C(O)SH + cistein desumporaza
Ovaj enzim prenosi sumpor i formira tiokarboksilatnu grupu na C-terminalnom glicinu male podjedinice enzima EC 2.8.1.12, molibdopterinske sintaze.
Reference[уреди | уреди извор]
- ^ Matthies, A., Nimtz, M. and Leimkuhler, S. (2005). „Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry”. Biochemistry. 44: 7912—7920. PMID 15910006.
- ^ Leimkuhler, S. & Rajagopalan, K.V. (2001). „A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli”. J. Biol. Chem. 276: 22024—22031. PMID 11290749.
- ^ Hanzelmann, P., Dahl, J.U., Kuper, J., Urban, A., Muller-Theissen, U., Leimkuhler, S. and Schindelin, H. (2009). „Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains”. Protein Sci. 18: 2480—2491. PMID 19798741.
- ^ Dahl, J.U., Urban, A., Bolte, A., Sriyabhaya, P., Donahue, J.L., Nimtz, M., Larson, T.J. and Leimkuhler, S. (2011). „The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli”. J. Biol. Chem. 286: 35801—35812. PMID 21856748.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Molybdopterin+synthase+sulfurtransferase на US National Library of Medicine Medical Subject Headings (MeSH)
