Peptidna deformilaza

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Peptidna deformilaza
EC broj
CAS broj 369636-51-1
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Peptidna deformilaza (EC, Peptide deformylase) je enzim sa sistematskim imenom formil-L-metionil peptid amidohidrolaza.[1][2][3][4][5][6][7][8][9][10][11][12] Ovaj enzim katalizuje sledeću hemijsku reakciju

formil-L-metionil peptid + H2O \rightleftharpoons format + metionil peptid

Za dejstvo ovog enzima je neophodno prisustvo Fe(II).


  1. ^ Adams, J.M. (1968). „On the release of the formyl group from nascent protein“. J. Mol. Biol. 33: 571-589. PMID 4973445. 
  2. ^ Mazel, D., Pochet, S. and Marliere, P. (1994). „Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation“. EMBO J. 13: 914-923. PMID 8112305. 
  3. ^ Chan, M.K., Gong, W., Rajagopalan, P.T.R., Hao, B., Tsai, C.M. and Pei, D. (1997). „Crystal structure of the Escherichia coli peptide deformylase“. Biochemistry 36: 13904-13909. PMID 9374869. 
  4. ^ Becker, A., Schlichting, I., Kabsch, W., Schultz, S. and Wagner, A.F.V. (1998). „Structure of peptide deformylase and identification of the substrate binding site“. J. Biol. Chem. 273: 11413-11416. PMID 9565550. 
  5. ^ Becker, A., Schlichting, I., Kabsch, W., Groche, D., Schultz, S. and Wagner, A.F. (1998). „Iron center, substrate recognition, and mechanism of peptide deformylase“. Nat. Struct. Biol. 5: 1053-1058. PMID 9846875. 
  6. ^ Rajagopalan, P.T.R., Yu, X.C. and Pei, D. (1997). „Peptide deformylase: a new type of mononuclear iron protein“. J. Am. Chem. Soc. 119: 12418-12419. 
  7. ^ Groche, D., Becker, A., Schlichting, I., Kabsch, W., Schultz, S. and Wagner, A.F.V. (1998). „Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site“. Biochem. Biophys. Res. Commun. 246: 342-346. PMID 9610360. 
  8. ^ Rajagopalan, P.T.R., Grimme, S. and Pei, D. (2000). „Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133“. Biochemistry 39: 779-790. PMID 10651644. 
  9. ^ Hu, Y.J., Wei, Y., Zhou, Y., Rajagopalan, P.T.R. and Pei, D. (1999). „Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library“. Biochemistry 38: 643-650. PMID 9888804. 
  10. ^ Ragasu, S., Mouchet, P., Lazennec, C., Dive, V. and Meinnel, T. (1999). „Substrate recognition and selectivity of peptide deformylase. Similarities and differences with metzincins and thermolysin“. J. Mol. Biol. 289: 1445-1457. PMID 10373378. 
  11. ^ Giglione, C., Pierre, M. and Meinnel, T. (2000). „Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents“. Mol. Microbiol. 36: 1197-1205. PMID 10931273. 
  12. ^ Pei, D. (2001). „Peptide deformylase: a target for novel antibiotics?“. Emerging Therapeutic Targets 5: 23-40. PMID 15992166. 


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