Bornil difosfatna sintaza

С Википедије, слободне енциклопедије
(преусмерено са (+)-bornil-difosfat lijaza (deciklizacija))
Bornil difosfatna sintaza
Identifikatori
EC broj5.5.1.8
CAS broj72668-91-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Bornil difosfatna sintaza (EC 5.5.1.8, bornil pirofosfatna sintaza, bornil pirofosfatna sintetaza, (+)-bornilpirofosfatna ciklaza, geranil-difosfatna ciklaza) je enzim sa sistematskim imenom (+)-bornil-difosfat lijaza (deciklizacija).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranil difosfat (+)-bornil difosfat

Za dejstvo ovog enzima je neophodan jon Mn2+.

Reference[уреди | уреди извор]

  1. ^ Croteau, R. & Karp, F. (1979). „Biosynthesis of monoterpenes: preliminary characterization of bornyl pyrophosphate synthetase from sage (Salvia officinalis) and demonstration that geranyl pyrophosphate is the preferred substrate for cyclization”. Arch. Biochem. Biophys. 198: 512—522. PMID 42356. 
  2. ^ Croteau, R., Gershenzon, J., Wheeler, C.J. and Satterwhite, D.M. (1990). „Biosynthesis of monoterpenes: stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to camphane and isocamphane monoterpenes”. Arch. Biochem. Biophys. 277: 374—381. PMID 2178556. 
  3. ^ Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1986). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 261: 13438—13445. PMID 3759972. 
  4. ^ Croteau, R., Felton, N.M. and Wheeler, C.J. (1985). „Stereochemistry at C-1 of geranyl pyrophosphate and neryl pyrophosphate in the cyclization to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 260: 5956—5962. PMID 3997807. 
  5. ^ Croteau, R.B., Shaskus, J.J., Renstrom, B., Felton, N.M., Cane, D.E., Saito, A. and Chang, C. (1985). „Mechanism of the pyrophosphate migration in the enzymatic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates”. Biochemistry. 24: 7077—7085. PMID 4084562. 
  6. ^ McGeady, P. & Croteau, R. (1995). „Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor”. Arch. Biochem. Biophys. 317: 149—155. PMID 7872777. 
  7. ^ Wise, M.L., Savage, T.J., Katahira, E. and Croteau, R. (1998). „Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase”. J. Biol. Chem. 273: 14891—14899. PMID 9614092. 
  8. ^ Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B. and Christianson, D.W. (2002). „Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase”. Proc. Natl. Acad. Sci. USA. 99: 15375—15380. PMID 12432096. 
  9. ^ Peters, R.J. & Croteau, R.B. (2003). „Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases”. Arch. Biochem. Biophys. 417: 203—211. PMID 12941302. 

Literatura[уреди | уреди извор]

Spoljašnje veze[уреди | уреди извор]