Dihidrolipoilizinski-ostatak (2-metilpropanoil)transferaza
(преусмерено са EC 2.3.1.168)
| Dihidrolipoilizinski-ostatak (2-metilpropanoil)transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.168 | ||||||||
| CAS broj | 102784-26-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dihidrolipoilizinski-ostatak (2-metilpropanoil)transferaza (EC 2.3.1.168, dihidrolipoil transacilaza, enzim-dihidrolipoillizin:2-metilpropanoil-KoA S-(2-metilpropanoil)transferaza, 2-metilpropanoil-KoA:enzim-6-N-(dihidrolipoil)lizin S-(2-metilpropanoil)transferaza) je enzim sa sistematskim imenom 2-metilpropanoil-KoA:enzim-N6-(dihidrolipoil)lizin S-(2-metilpropanoil)transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-metilpropanoil-KoA + enzim N6-(dihidrolipoil)lizin KoA + enzim N6-(S-[2-metilpropanoil]dihidrolipoil)lizin
Ova enzim je multimer (24-mer). On formira osnovu multienzimskog kompleksa 3-metil-2-oksobutanoat dehidrogenaze, i čvrsto vezuje EC 1.2.4.4, 3-metil-2-oksobutanoat dehidrogenazu (2-metilpropanoil-transfer) i EC 1.8.1.4, dihidrolipoil dehidrogenazu.
Reference[уреди | уреди извор]
- ^ Massey, L.K., Sokatch, J.R. and Conrad, R.S. (1976). „Branched-chain amino acid catabolism in bacteria”. Bacteriol. Rev. 40: 42—54. PMID 773366.
- ^ Chuang, D.T., Hu, C.C., Ku, L.S., Niu, W.L., Myers, D.E. and Cox, R.P. (1984). „Catalytic and structural properties of the dihydrolipoyl transacylase component of bovine branched-chain α-keto acid dehydrogenase”. J. Biol. Chem. 259: 9277—9284. PMID 6746648.
- ^ Wynn, R.M., Davie, J.R., Zhi, W., Cox, R.P. and Chuang, D.T. (1994). „In vitro reconstitution of the 24-meric E2 inner core of bovine mitochondrial branched-chain α-keto acid dehydrogenase complex: requirement for chaperonins GroEL and GroES”. Biochemistry. 33: 8962—8968. PMID 7913832.
- ^ Perham, R.N. (2000). „Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions”. Annu. Rev. Biochem. 69: 961—1004. PMID 10966480.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Dihydrolipoyllysine-residue+(2-methylpropanoyl)transferase на US National Library of Medicine Medical Subject Headings (MeSH)
