Piroglutamilna peptidaza II
(преусмерено са Piroglutamil-peptidaza II)
| Piroglutamilna peptidaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.6 | ||||||||
| CAS broj | 60063-88-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Piroglutamilna peptidaza II (EC 3.4.19.6, tiroliberinaza, piroglutamilna aminopeptidaza II, , tirotropin-oslobađajući faktor piroglutamatna aminopeptidaza, piroglutamatna aminopeptidaza II, tiroliberin-hidrolizujuća piroglutamatna aminopeptidaza, tirotropin-oslobađajuća hormon-degradirajuća piroglutamatna aminopeptidaza, tirotropin-oslobađajuća hormon-degradirajuća peptidaza, TRH aminopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalne piroglutamilne grupe sa pGlu-His-Xaa tripeptida i pGlu-His-Xaa-Gly tetrapeptida
Ovaj enzim je visoko specifičan za tireotropin oslobađajući hormon.
Reference[уреди | уреди извор]
- ^ Bauer, K. & Nowak, P. (1979). „Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond”. Eur. J. Biochem. 99: 239—246. PMID 115687.
- ^ O'Connor, B. & O'Cuinn, G. (1985). „Purification of and kinetic studies on a narrow specifity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain”. Eur. J. Biochem. 150: 47—52. PMID 2862039.
- ^ Wilk, S. & Wilk, E.K. (1989). „Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme”. Neurochem. Int. 15: 81—89.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Pyroglutamyl-peptidase+II на US National Library of Medicine Medical Subject Headings (MeSH)
