Srebro diamin fluorid

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Srebro diamin fluorid
Klinički podaci
Prodajno ime Saforide, Advantage Arrest, Cariesop, Bioride, FluoroplatV, Riva Star
Pravni status
Pravni status
  • US: Rx-samo, 510(k) odbrena klasa II
Identifikatori
CAS broj 34445-07-3
ChemSpider 142121
UNII DDU19UEV1 ДаY
Sinonimi Diamin srebro fluorida
Hemijski podaci
Formula AgF(NH3)2
Molarna masa 160.927643 g/mol[1]

Srebro diamin fluorid je topikalni lek koji se koristi za tretiranje i prevenciju karijesa i olakšavanje dentiske hiperzenzitivnosti.[2][3] Srebro diamin fluorid je već decenijama dostupan u mnogim zemljama uključujući Kinu, Japan, Novi Zeland, Australiju i druge. Ovaj proizvod je FDA odobrila za prodaju u SAD u avgustu 2014 kao medicinsko sredstvo klase II za tretiranje dentinske hipersenzitivnosti.[4]

Klinička evidencija[уреди]

Šest randomizovanih kliničkih ispitivanja potvrđuju znatnu delotvornost ovog materijala u zatvaranju šupljina zuba, jednostavnim sušenjem šupljine i unosom ovog materijal.[5][6][7][8][9][10][11]

Dva randomizovana klinička ispitivanja potvrđuju efekte ovog leka u prevenciji formiraja šupljina, primenom na površine koje imaju šušljine.[5][6][7] Četiri randomizovana klinička ispitivanja su potvrdila znatan impakt u sprečavanju formiranja šušljina.[11][12][13][14]

Nomenklatura[уреди]

Razlike u nomenklaturi su dovodile do zabune. Srebro diamin fluorid je takođe poznat kao:

  • srebro fluorid,
  • srebro diamin fluorid,
  • diamin srebro fluorid,
  • amonijačni srebro fluorid

Reference[уреди]

  1. ^ „SILVERDIAMINEFLUORIDE (CAS No. 34445-07-3) Suppliers @ ChemicalRegister.com”. chemicalregister.com. Приступљено 14. 7. 2016. 
  2. ^ Craig GG, Knight GM, McIntyre JM (2012). „Clinical evaluation of diamine silver fluoride/potassium iodide as a dentine desensitizing agent. A pilot study”. Aust Dent J. 57: 308—11. PMID 22924353. doi:10.1111/j.1834-7819.2012.01700.x. 
  3. ^ Mei, May L.; Ito, L.; Cao, Y.; Li, Q.L.; Chu, C.H.; Lo, Edward C.M. (3. 12. 2013). „The inhibitory effects of silver diamine fluorides on cysteine cathepsins”. 42 (3): 329—335. doi:10.1016/j.jdent.2013.11.018. Приступљено 14. 7. 2016. 
  4. ^ http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K102973
  5. 5,0 5,1 Chu CH, Lo ECM, Lin HC. Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. Journal of Dental Research. 2002;81(11):767-770.
  6. 6,0 6,1 Lo EC, Chu CH, Lin HC. A community-based caries control program for pre-school children using topical fluorides: 18-month results. Journal of Dental Research. 2001;80(12):2071-2074.
  7. 7,0 7,1 Llodra JC, Rodriguez A, Ferrer B, Menardia V, Ramos T, Morato M. Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. Journal of Dental Research. 2005;84(8):721-724.
  8. ^ Yee R, Holmgren C, Mulder J, Lama D, Walker D, van Palenstein Helderman W. Efficacy of silver diamine fluoride for Arresting Caries Treatment. Journal of Dental Research. 2009;88(7):644-647.
  9. ^ Zhi QH, Lo ECM, Lin HC. Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. Journal of Dentistry. 2012;40(11):962-967.
  10. ^ Santos Dos VE, de Vasconcelos FMN, Ribeiro AG, Rosenblatt A. Paradigm shift in the effective treatment of caries in school children at risk. International Dental Journal. 2012;62(1):47-51.
  11. 11,0 11,1 Zhang W, McGrath C, Lo ECM, Li JY. Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. Caries Res. 2013;47(4):284-290.
  12. ^ Tan HP, Lo ECM, Dyson JE, Luo Y, Corbet EF. A randomized trial on root caries prevention in elders. Journal of Dental Research. 2010;89(10):1086-1090.
  13. ^ Liu BY, Lo ECM, Chu CH, Lin HC. Randomized trial on fluorides and sealants for fissure caries prevention. Journal of Dental Research. 2012;91(8):753-758.
  14. ^ Monse B, Heinrich-Weltzien R, Mulder J, Holmgren C, van Palenstein Helderman WH. Caries preventive efficacy of silver diammine fluoride (SDF) and ART sealants in a school-based daily fluoride toothbrushing program in the Philippines. BMC Oral Health. 2012;12(1):52.