TRNK intron endonukleaza
(преусмерено са TRNK-intron endonukleaza)
| TRNK intron endonukleaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.27.9 | ||||||||
| CAS broj | 117444-13-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK intron endonukleaza (EC 3.1.27.9, transferna ribonukleat intronska endoribonukleaza, tRNK splajsujuća endonukleaza, splajsujuća endonukleaza, tRNKTRPintron endonukleaza, transferna splajsujuća endonukleaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endonukleolitičko razlaganje pre-tRNK, formiranje 5'-hidroksi i 2',3'-ciklično fosfatnih krajeva, i specifično uklanjanje introna
Ovaj enzim katalizuje finalni stupanj maturacije tRNK molekula.
Reference[уреди | уреди извор]
- ^ Attardi, D.G., Margarit, I. and Tocchini-Valentini, G.P. (1985). „Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease”. EMBO J. 4: 3289—3297. PMID 3937725.
- ^ Peebles, C.L., Gegenheimer, P. and Abelson, J. (1983). „Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease”. Cell. 32: 525—536. PMID 6186398.
- ^ Thompson, L.D., Brandon, L.D., Nieuwlandt, D.T. and Daniels, C.J. (1989). „Transfer RNA intron processing in the halophilic archaebacteria”. Can. J. Microbiol. 35: 36—42. PMID 2470486.
- ^ Thompson, L.D. & Daniels, C.J. (1988). „A tRNA(Trp) intron endonuclease from Halobacterium volcanii. Unique substrate recognition properties”. J. Biol. Chem. 263: 17951—17959. PMID 3192521.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- TRNA-intron+endonuclease на US National Library of Medicine Medical Subject Headings (MeSH)
