D-Man-alfa-(1-3)-D-Glc-beta-(1-4)-D-Glc-alfa-1-difosfoundekaprenol 2-beta-glukuroniltransferaza
| D-Man-alfa-(1->3)-D-Glc-beta-(1->4)-D-Glc-alfa-1-difosfoundekaprenol 2-beta-glukuroniltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.264 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D-Man-alfa-(1->3)-D-Glc-beta-(1->4)-D-Glc-alfa-1-difosfoundekaprenol 2-beta-glukuroniltransferaza (EC 2.4.1.264, GumK) je enzim sa sistematskim imenom UDP-glukuronat:D-Man-alfa-(1->3)-D-Glc-beta-(1->4)-D-Glc-alfa-1-difosfo-ditrans,oktacis-undekaprenol beta-1,2-glukuroniltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-glukuronat + D-Man-alfa-(1->3)-D-Glc-beta-(1->4)-D-Glc-alfa-1-difosfo-ditrans,oktacis-undekaprenol UDP + D-GlcA-beta-(1->2)-D-Man-alfa-(1->3)-D-Glc-beta-(1->4)-D-Glc-alfa-1-difosfo-ditrans,oktacis-undekaprenol
Ovaj enzim učestvuje u biosintezi eksopolisaharida ksantana (kod bakterije Xanthomonas campestris) i acetana (kod bakterije Glukonacetobacter xylinus).
Reference[уреди | уреди извор]
- ^ Katzen, F., Ferreiro, D.U., Oddo, C.G., Ielmini, M.V., Becker, A., Puhler, A. and Ielpi, L. (1998). „Xanthomonas campestris' pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence”. J. Bacteriol. 180: 1607—1617. PMID 9537354.
- ^ Ielpi, L., Couso, R.O. and Dankert, M.A. (1993). „Sequential assembly and polymerization of the polyprenol-linked pentasaccharide repeating unit of the xanthan polysaccharide in Xanthomonas campestris”. J. Bacteriol. 175: 2490—2500. PMID 7683019.
- ^ Kim, S.Y., Kim, J.G., Lee, B.M. and Cho, J.Y. (2009). „Mutational analysis of the gum gene cluster required for xanthan biosynthesis in Xanthomonas oryzae' pv oryzae”. Biotechnol. Lett. 31: 265—270. PMID 18854951.
- ^ Barreras, M., Bianchet, M.A. and Ielpi, L. (2006). „Crystallization and preliminary crystallographic characterization of GumK, a membrane-associated glucuronosyltransferase from Xanthomonas campestris required for xanthan polysaccharide synthesis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62: 880—883. PMID 16946469.
- ^ Barreras, M., Salinas, S.R., Abdian, P.L., Kampel, M.A. and Ielpi, L. (2008). „Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase”. J. Biol. Chem. 283: 25027—25035. PMID 18596046.
- ^ Vojnov, A.A., Bassi, D.E., Daniels, M.J. and Dankert, M.A. (2002). „Biosynthesis of a substituted cellulose from a mutant strain of Xanthomonas campestris”. Carbohydr. Res. 337: 315—326. PMID 11841812.
- ^ Barreras, M., Abdian, P.L. and Ielpi, L. (2004). „Functional characterization of GumK, a membrane-associated β-glucuronosyltransferase from Xanthomonas campestris required for xanthan polysaccharide synthesis”. Glycobiology. 14: 233—241. PMID 14736729.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- >3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol%202-beta-glucuronyltransferase D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol+2-beta-glucuronyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
