Denileukin diftitoks
| Klinički podaci | |
|---|---|
| Drugs.com | diftitox.html Monografija |
| Način primene | Intravenozno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 70-80 min |
| Identifikatori | |
| CAS broj | 173146-27-5  |
| ATC kod | L01XX29 (WHO) |
| DrugBank | DB00004 |
| ChEMBL | CHEMBL1201550 |
| Hemijski podaci | |
| Formula | C2560H4042N678O799S17 |
| Molarna masa | 57647,3 g/mol |
Denileukin diftitoks (Ontak) je antineoplastični agens, dizajnirani protein koji je kombinacija interleukina 2 i toksina difterije. Ovaj molekul se vezuje za interleukin-2 receptore[1] i unosi toksin difterije u ćelija koje izražavaju te receptore, što dovodi do njihove smrti. Denileukin diftitoks se proizvodi u E. coli ekspresioni sistem.[2][3][4][5]
Reference[уреди | уреди извор]
- ^ Turturro F (2007). „Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders”. Expert Rev Anticancer Ther. 7 (1): 11—7. PMID 17187516. doi:10.1586/14737140.7.1.11.
- ^ Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7. PMID 17187516
- ^ Park M, Liu GT, Piltz-Seymour J, Wisda CL, Rook AH, Junkins-Hopkins JM, Nasta SD, Kim EJ: Vision loss following denileukin diftitox treatment: a case report of possible posterior ischemic optic neuropathy. Leuk Lymphoma. 2007 Apr;48(4):808-11. PMID 17454642
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
Literatura[уреди | уреди извор]
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
