Glukozilkeramid beta-1,4-galaktoziltransferaza
| Glukozilkeramid beta-1,4-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.274 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glukozilkeramid beta-1,4-galaktoziltransferaza (EC 2.4.1.274, laktozilkeramidna sintaza, uridin difosfat-galaktoza:glukozil keramid beta 1-4 galaktoziltransferaza, UDP-Gal:glukozilkeramid beta1->4galaktoziltransferaza, GalT-2, UDP-galaktoza:beta-D-glukozil-(1<->1)-keramid beta-1,4-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:beta-D-glukozil-(1<->1)-keramid 4-beta-D-galaktoziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + beta-D-glukozil-(1<->1)-keramid UDP + beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid
Ovaj enzim učestvuje u sintezi nekoliko različitih klasa glikosfingolipida.
Reference[уреди | уреди извор]
- ^ Chatterjee, S. & Castiglione, E. (1987). „UDPgalactose:glucosylceramide β1→4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes”. Biochim. Biophys. Acta. 923: 136—142. PMID 3099851.
- ^ Trinchera, M., Fiorilli, A. and Ghidoni, R. (1991). „Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide β1→4galactosyltransferase”. Biochemistry. 30: 2719—2724. PMID 1900430.
- ^ Chatterjee, S., Ghosh, N. and Khurana, S. (1992). „Purification of uridine diphosphate-galactose:glucosyl ceramide, β 1-4 galactosyltransferase from human kidney”. J. Biol. Chem. 267: 7148—7153. PMID 1551920.
- ^ Nomura, T., Takizawa, M., Aoki, J., Arai, H., Inoue, K., Wakisaka, E., Yoshizuka, N., Imokawa, G., Dohmae, N., Takio, K., Hattori, M. and Matsuo, N. (1998). „Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide β-1,4-galactosyltransferase from rat brain”. J. Biol. Chem. 273: 13570—13577. PMID 9593693.
- ^ Takizawa, M., Nomura, T., Wakisaka, E., Yoshizuka, N., Aoki, J., Arai, H., Inoue, K., Hattori, M. and Matsuo, N. (1999). „cDNA cloning and expression of human lactosylceramide synthase”. Biochim. Biophys. Acta. 1438: 301—304. PMID 10320813.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Glucosylceramide+beta-1,4-galactosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
