Laktozilkeramid 4-a-galaktoziltransferaza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktozilkeramid 4-a-galaktoziltransferaza
Laktozilkeramid 4-a-galaktoziltransferaza
Identifikatori
EC broj	2.4.1.228
CAS broj	52725-57-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktozilkeramid 4-a-galaktoziltransferaza (EC 2.4.1.228, Galbeta1-4Glcbeta1-Cer alfa1,4-galaktoziltransferaza, globotriaozilkeramid/CD77 sintaza, histo-krvna grupa Pk UDP-galaktoza, UDP-galaktoza:laktozilkeramid 4II-alfa-D-galaktoziltransferaza, UDP-galaktoza:beta-D-galaktozil-(1->4)-D-glukozil(1<->1)keramid 4II-alfa-D-galaktoziltransferaza, UDP-galaktoza:beta-D-galaktozil-(1->4)-D-glukozil-(1<->1)-keramid 4II-alfa-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:beta-D-galaktozil-(1->4)-D-glukozil-(1<->1)-keramid 4II-alfa-D-galaktoziltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-galaktoza + beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

\rightleftharpoons

UDP + alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

Reference[уреди | уреди извор]

^ Bailly, P., Piller, F., Cartron, J.P., Leroy, Y. and Fournet, B. (1986). „Identification of UDP-galactose: lactose (lactosylceramide) α-4 and β-3 galactosyltransferases in human kidney”. Biochem. Biophys. Res. Commun. 141: 84—91. PMID 3099784.
^ Steffensen, R., Carlier, K., Wiels, J., Levery, S.B., Stroud, M., Cedergren, B., Nilsson Sojka, B., Bennett, E.P., Jersild, C. and Clausen, H. (2000). „Cloning and expression of the histo-blood group Pk UDP-galactose: Galβ1-4Glcβ1-Cer α1,4-galactosyltransferase. Molecular genetic basis of the p phenotype”. J. Biol. Chem. 275: 16723—16729. PMID 10747952.
^ Kojima, Y., Fukumoto, S., Furukawa, K., Okajima, T., Wiels, J., Yokoyama, K., Suzuki, Y., Urano, T., Ohta, M. and Furukawa, K. (2000). „Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids”. J. Biol. Chem. 275: 15152—15156. PMID 10748143.

Literatura[уреди | уреди извор]

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze[уреди | уреди извор]

Lactosylceramide+4-alpha-galactosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Bailly, P., Piller, F., Cartron, J.P., Leroy, Y. and Fournet, B. (1986). „Identification of UDP-galactose: lactose (lactosylceramide) α-4 and β-3 galactosyltransferases in human kidney”. Biochem. Biophys. Res. Commun. 141: 84—91. PMID 3099784.

[2] Steffensen, R., Carlier, K., Wiels, J., Levery, S.B., Stroud, M., Cedergren, B., Nilsson Sojka, B., Bennett, E.P., Jersild, C. and Clausen, H. (2000). „Cloning and expression of the histo-blood group Pk UDP-galactose: Galβ1-4Glcβ1-Cer α1,4-galactosyltransferase. Molecular genetic basis of the p phenotype”. J. Biol. Chem. 275: 16723—16729. PMID 10747952.

[3] Kojima, Y., Fukumoto, S., Furukawa, K., Okajima, T., Wiels, J., Yokoyama, K., Suzuki, Y., Urano, T., Ohta, M. and Furukawa, K. (2000). „Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids”. J. Biol. Chem. 275: 15152—15156. PMID 10748143.

[1]

[2]

[3]

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6