Mitogenom-aktivirana proteinska kinaza 1

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Mitogenom-aktivirana proteinska kinaza 1

PDB prikaz baziran na PDB 1erk.
Dostupne strukture
1erk, 1gol, 1pme, 1tvo, 1wzy, 2erk, 2fys, 2gph, 2ojg, 2oji, 2ojj, 3erk, 4erk
Identifikatori
Simboli MAPK1; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk
Vanjski ID OMIM176948 MGI1346858 HomoloGene37670 GeneCards: MAPK1 Gene
Pregled RNK izražavanja
PBB GE MAPK1 212271 at.png
PBB GE MAPK1 208351 s at.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5594 26413
Ensembl ENSG00000100030 ENSMUSG00000063358
UniProt P28482 Q3UF82
RefSeq (mRNA) NM_002745 NM_001038663
RefSeq (protein) NP_002736 NP_001033752
Lokacija (UCSC) Chr 22:
20.45 - 20.55 Mb
Chr 16:
16.9 - 16.96 Mb
PubMed pretraga [1] [2]

Mitogenom-aktivirana proteinska kinaza 1, takođe poznata kao MAPK1, p42MAPK, i ERK2, je enzim koji je kod ljudi kodiran MAPK1 genom.[1]

Funkcije[уреди]

Protein kodiran ovim genom je član familije MAP kinaza. Mitogenom-aktivirane proteinske kinaze, su takođe poznate kao ekstracelularnim signalom regulisane kinaze (ERK). One deluju kao tačka integracije višestrukih biohemijskih signala, i učestvuju u širokom varijetetu ćelijskih procesa kao što su proliferacija, diferencijacija, i regulacija transkripcije i razvoja. Prirekvizit aktivacije ove kinaze je njena fosforilisana uzvodnim kinazama. Nakon aktivacije, ova kinaza se translocira u jedro stimulisanih ćelija, gde ona fosforiliše proteine jedra. Dve alternativno splajsovane transkriptne varijante, koje se razlikuju u netranskribovanim regionima, kodiraju isti protein.[2]

Interakcije[уреди]

Za MAPK1 je bilo pokazano da interaguje sa TSC2,[3] PEA15,[4] DUSP1,[5][6] NEK2,[7] DUSP3,[8] STAT5A,[9][10] MAPK14,[11][12] FHL2,[13] TNIP1,[14] RPS6KA3,[15][16] RPS6KA2,[15][17] MAP2K1,[11][18][19][20][21][22] RPS6KA1,[16][17][23] PTPN7,[24][25] MKNK1,[26] CIITA,[27] TOB1,[28] Fosfatidiletanolamin vezujući protein 1,[19] DUSP22,[29] Myc,[30][31][32] ADAM17,[33] SORBS3,[34] ELK1,[23][35] VAV1,[36][37] HDAC4,[38] MKNK2,[26][39] MAP3K1[40] i UBR5.[23]

Reference[уреди]

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