N-acetil-beta-glukozaminil-glikoprotein 4-beta-N-acetilgalaktozaminiltransferaza
| N-acetil-beta-glukozaminil-glikoprotein 4-beta-N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.244 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-acetil-beta-glukozaminil-glikoprotein 4-beta-N-acetilgalaktozaminiltransferaza (EC 2.4.1.244, beta1,4-N-acetilgalaktozaminiltransferaza III, beta4GalNAc-T3, beta1,4-N-acetilgalaktozaminiltransferaza IV, beta4GalNAc-T4, UDP-N-acetil-D-galaktozamin:N-acetil-D-glukozaminil-grupa beta-1,4-N-acetilgalaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:N-acetil-beta-D-glukozaminil-grupa 4-beta-N-acetilgalaktozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-galaktozamin + N-acetil-beta-D-glukozaminilna grupa UDP + N-acetil-beta-D-galaktozaminil-(1->4)-N-acetil-beta-D-glukozaminilna grupa
Ljudski enzim može da prenese N-acetil-D-galaktozamin (GalNAc) na N-glikanski i O-glikanski supstrat koji ima N-acetil-D-glukozamin (GlcNAc).
Reference[уреди | уреди извор]
- '^ Sato, T., Gotoh, M., Kiyohara, K., Kameyama, A., Kubota, T., Kikuchi, N., Ishizuka, Y., Iwasaki, H., Togayachi, A., Kudo, T., Ohkura, T., Nakanishi, H. and Narimatsu, H. (2003). „Molecular cloning and characterization of a novel human β1,4-N-acetylgalactosaminyltransferase, β4GalNAc-T3, responsible for the synthesis of N,N-diacetyllactosediamine, GalNAc β1-4GlcNAc”. J. Biol. Chem. 278: 47534—47544. PMID 12966086.
- '^ Gotoh, M., Sato, T., Kiyohara, K., Kameyama, A., Kikuchi, N., Kwon, Y.D., Ishizuka, Y., Iwai, T., Nakanishi, H. and Narimatsu, H. (2004). „Molecular cloning and characterization of β1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N-diacetyllactosediamine”. FEBS Lett. 562: 134—140. PMID 15044014.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- N-acetyl-beta-glucosaminyl-glycoprotein+4-beta-N-acetylgalactosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
