8-Амино-7-оксононаноат синтаза
| 8-amino-7-oksononanoat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.47 | ||||||||
| CAS broj | 9075-61-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
8-amino-7-oksononanoat sintaza (EC 2.3.1.47, 7-keto-8-aminopelargonsko kiselinska sintetaza, 7-keto-8-aminopelargonska sintetaza, 8-amino-7-oksopelargonatna sintaza) je enzim sa sistematskim imenom 6-karboksiheksanoil-KoA:L-alanin C-karboksiheksanoiltransferaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 6-karboksiheksanoil-KoA + L-alanin 8-amino-7-oksononanoat + KoA + CO2
Ovaj enzim je piridoksal-fosfatni protein.
Reference
[уреди | уреди извор]- ^ Eisenberg, M.A. & Star, C. (1968). „Synthesis of 7-oxo-8-aminopelargonic acid, a biotin vitamer, in cell-free extracts of Escherichia coli biotin auxotrophs”. J. Bacteriol. 96: 1291—1297. PMID 4879561.
- ^ Alexeev, D., Alexeeva, M., Baxter, R.L., Campopiano, D.J., Webster, S.P. and Sawyer, L. (1998). „The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme”. J. Mol. Biol. 284: 401—419. PMID 9813126.
- ^ Ploux, O., Breyne, O., Carillon, S. and Marquet, A. (1999). „Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5′-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies”. Eur. J. Biochem. 259: 63—70. PMID 9914476.
- ^ Webster, S.P. (2000). „, Alexeev. D., Campopiano, D.J., Watt, R.M., Alexeeva, M., Sawyer, L. and Baxter, R. Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies”. Biochemistry. 39: 516—528. PMID 10642176.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- 8-amino-7-oxononanoate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
