Витамин-К-епоксид редуктаза (варфарин-сенситивна)
| Vitamin-K-epoksid reduktaza (varfarin-sensitivna) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.4.1 | ||||||||
| CAS broj | 55963-40-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Vitamin-K-epoksid reduktaza (varfarin-sensitivna) (EC 1.1.4.1, vitamin-K-epoksidna reduktaza (varfarin-sensitivna)) je enzim sa sistematskim imenom 2-metil-3-fitil-1,4-naftohinon:oksidovani-ditiotreitol oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 2-metil-3-fitil-1,4-naftohinon + oksidovani ditiotreitol 2,3-epoksi-2,3-dihidro-2-metil-3-fitil-1,4-naftohinon + 1,4-ditiotreitol
U reverznoj reakciji se vitamin K 2,3-epoksid redukuje do vitamina K, a potencijalno i do vitamin K hidrohinona posrestvom 1,4-ditiotreitola, koji se oksiduje do disulfida.
Reference
[уреди | уреди извор]- ^ Lee, J.L. & Fasco, M.J. (1984). „Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide”. Biochemistry. 23: 2246—2252. PMID 6733086.
- ^ Mukharji, I. & Silverman, R.B. (1985). „Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone”. Proc. Natl. Acad. Sci. USA. 82: 2713—2717. PMID 3857611.
- ^ Whitlon, D.S., Sadowski, J.A. and Suttie, J.W. (1978). „Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition”. Biochemistry. 17: 1371—1377. PMID 646989.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Vitamin-K-epoxide+reductase+(warfarin-sensitive) на US National Library of Medicine Medical Subject Headings (MeSH)
