3a(17b)-hidroksisteroid dehidrogenaza (NAD+)
Appearance
3a(17b)-hidroksisteroid dehidrogenaza (NAD+) | |||||||||
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Identifikatori | |||||||||
EC broj | 1.1.1.239 | ||||||||
CAS broj | 126469-82-7 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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3a(17b)-hidroksisteroid dehidrogenaza (NAD+) (EC 1.1.1.239, 3alfa,17beta-hidroksi steroid dehidrogenaza, 3alfa(17beta)-HSD, 17-ketoreduktaza (ambiguous), 17beta-HSD, HSD17B6, HSD17B8) je enzim sa sistematskim imenom 3alfa(or 17beta)-hidroksisteroid:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- testosteron + NAD+ androstendion + NADH + H+
Reference
[uredi | uredi izvor]- ^ Sweat, M.L., Samuels, L.T. and Lumry, R. (1950). „Preparation and characterisation of the enzyme which converts testosterone to androstendione”. J. Biol. Chem. 185: 75—84. PMID 15436478.
- ^ Villee, C.A. & Spencer, J.M. (1960). „Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 3615—3619. PMID 13781425.
- ^ Endahl, G.L., Kochakia, C.D. and Hamm, D. (1960). „Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 2792—2796. PMID 13696735.
- ^ Ohmura, M., Hara, A., Nakagawa, M. and Sawada, H. (1990). „Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver”. Biochem. J. 266: 583—589. PMID 2317205.
Literatura
[uredi | uredi izvor]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[uredi | uredi izvor]- 3alpha(17beta)-hydroxysteroid+dehydrogenase+(NAD+) na US National Library of Medicine Medical Subject Headings (MeSH)