3a(17b)-hidroksisteroid dehidrogenaza (NAD+)

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3a(17b)-hidroksisteroid dehidrogenaza (NAD⁺)
3a(17b)-hidroksisteroid dehidrogenaza (NAD+)
Identifikatori
EC broj	1.1.1.239
CAS broj	126469-82-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

3a(17b)-hidroksisteroid dehidrogenaza (NAD⁺) (EC 1.1.1.239, 3alfa,17beta-hidroksi steroid dehidrogenaza, 3alfa(17beta)-HSD, 17-ketoreduktaza (ambiguous), 17beta-HSD, HSD17B6, HSD17B8) je enzim sa sistematskim imenom 3alfa(or 17beta)-hidroksisteroid:NAD⁺ oksidoreduktaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

testosteron + NAD⁺

\rightleftharpoons

androstendion + NADH + H⁺

Reference

^ Sweat, M.L., Samuels, L.T. and Lumry, R. (1950). „Preparation and characterisation of the enzyme which converts testosterone to androstendione”. J. Biol. Chem. 185: 75—84. PMID 15436478.
^ Villee, C.A. & Spencer, J.M. (1960). „Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 3615—3619. PMID 13781425.
^ Endahl, G.L., Kochakia, C.D. and Hamm, D. (1960). „Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 2792—2796. PMID 13696735.
^ Ohmura, M., Hara, A., Nakagawa, M. and Sawada, H. (1990). „Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver”. Biochem. J. 266: 583—589. PMID 2317205.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

3alpha(17beta)-hydroxysteroid+dehydrogenase+(NAD+) na US National Library of Medicine Medical Subject Headings (MeSH)

[1] Sweat, M.L., Samuels, L.T. and Lumry, R. (1950). „Preparation and characterisation of the enzyme which converts testosterone to androstendione”. J. Biol. Chem. 185: 75—84. PMID 15436478.

[2] Villee, C.A. & Spencer, J.M. (1960). „Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 3615—3619. PMID 13781425.

[3] Endahl, G.L., Kochakia, C.D. and Hamm, D. (1960). „Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 2792—2796. PMID 13696735.

[4] Ohmura, M., Hara, A., Nakagawa, M. and Sawada, H. (1990). „Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver”. Biochem. J. 266: 583—589. PMID 2317205.

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[2]

[3]

[4]

p r u Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6