Dopastin
Appearance
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Nazivi | |
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Sistemski IUPAC naziv
(2E)-N(2S)-2-[Hidroksi(nitrozo)amino]-3-metilbutil2-butenamid | |
Identifikacija | |
3D model (Jmol)
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ChemSpider | |
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Svojstva | |
C9H17N3O3 | |
Molarna masa | 215,25 g·mol−1 |
Tačka topljenja | 116-119 °C[3] |
Kiselost (pKa) | 5,1[3] |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
Reference infokutije | |
Dopastin je hemijsko jedinjenje koje formira bakterija Pseudomonas No. BAC-125.[4] Ono je prvi put izolovano i okarakterisano 1972. Dopastin deluje kao inhibitor enzima dopaminska β-hidroksilaza.[5]
Dopastin se može sintetički pripremiti iz L-valinola.[6]
Reference
[uredi | uredi izvor]- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ а б The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th изд.). Merck Publishing. 1989. ISBN 091191028X., pages+3417 </noinclude>
- ^ Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). „Dopastin, an inhibitor of dopamine -hydroxylase”. The Journal of antibiotics. 25 (8): 497—500. PMID 4648494.
- ^ H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). „Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase”. Agric. Biol. Chem. 38 (11): 2107—2111. doi:10.1271/bbb1961.38.2107.
- ^ Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). „Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin”. Journal of the Chemical Society, Chemical Communications (4): 147. doi:10.1039/C39730000147.