L-lizinska ciklodeaminaza
| L-lizinska ciklodeaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.1.28 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-lizinska ciklodeaminaza (EC 4.3.1.28, rapL (gen), fkbL (gen), tubZ (gen), visC (gen)) je enzim sa sistematskim imenom L-lizin amonijak-lijaza (ciklizacija, formira amonijak).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-lizin L-pipekolat + NH3
Za dejstvo ovog enzma je neophodan NAD+.
Reference
[uredi | uredi izvor]- ^ Khaw, L.E., Bohm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. (1998). „Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase”. J. Bacteriol. 180: 809—814. PMID 9473033.
- ^ Gatto, G.J., Jr., Boyne, M.T., 2nd, Kelleher, N.L. and Walsh, C.T. (2006). „Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster”. J. Am. Chem. Soc. 128: 3838—3847. PMID 16536560.
- ^ Tsotsou, G.E. & Barbirato, F. (2007). „Biochemical characterisation of recombinant Streptomyces pristinaespiralis L-lysine cyclodeaminase”. Biochimie. 89: 591—604. PMID 17291665.
Literatura
[uredi | uredi izvor]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[uredi | uredi izvor]- L-lysine+cyclodeaminase na US National Library of Medicine Medical Subject Headings (MeSH)
