Sepiapterin reduktaza
| Sepiapterin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.153 | ||||||||
| CAS broj | 9059-48-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sepiapterin reduktaza (EC 1.1.1.153, sepiapterinska reduktaza) je enzim sa sistematskim imenom L-eritro-7,8-dihidrobiopterin:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-eritro-7,8-dihidrobiopterin + NADP+ sepiapterin + NADPH + H+
- L-eritro-tetrahidrobiopterin + 2 NADP+ 6-piruvoil-5,6,7,8-tetrahidropterin + 2 NADPH + 2 H+
Ovaj enzim katalizuje finalni korak de novo sinteze tetrahidrobiopterina iz GTP-a. Enzim koji je prisutan kod viših životinja i nekih gljiva i bakterija, proizvodi eritro formu tetrahidrobiopterina, cf. EC 1.1.1.325, sepiapterin reduktaza (formira L-treo-7,8-dihidrobiopterin).
Reference[uredi | uredi izvor]
- ^ Katoh, S. (1971). „Sepiapterin reductase from horse liver: purification and properties of the enzyme”. Arch. Biochem. Biophys. 146: 202—214. PMID 4401291.
- ^ Matsubara, M., Katoh, S., Akino, M. and Kaufman, S. (1966). „Sepiapterin reductase”. Biochim. Biophys. Acta. 122: 202—212. PMID 5969298.
- ^ Werner, E.R., Schmid, M., Werner-Felmayer, G., Mayer, B. and Wachter, H. (1994). „Synthesis and characterization of 3H-labelled tetrahydrobiopterin”. Biochem. J. 304: 189—193. PMID 7528005.
- ^ Kim, Y.A., Chung, H.J., Kim, Y.J., Choi, Y.K., Hwang, Y.K., Lee, S.W. and Park, Y.S. (2000). „Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli”. Mol. Cells. 10: 405—410. PMID 10987137.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[uredi | uredi izvor]
- Sepiapterin+reductase na US National Library of Medicine Medical Subject Headings (MeSH)
