Glutaminil-peptid ciklotransferaza
| Glutaminil-peptid ciklotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.2.5 | ||||||||
| CAS broj | 37257-21-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutaminil-peptid ciklotransferaza (EC 2.3.2.5, glutaminil-tRNK ciklotransferaza, glutaminil ciklaza, glutaminil-transfer ribonukleatna ciklotransferaza) je enzim sa sistematskim imenom L-glutaminil-peptid gama-glutamiltransferaza (ciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-glutaminil-peptid 5-oksoprolil-peptid + NH3
Ovaj enzim učestvuje u formiranju tirotropin oslobađajućeg hormona i drugih biološki aktivnih peptida koji sadrže N-terminalne piroglutamilne ostatke.
Reference[уреди | уреди извор]
- ^ Busby, W.H., Quackenbush, G.E., Humm, J., Youngblood, W.W. and Kizer, J.S. (1987). „An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes”. J. Biol. Chem. 262: 8532—8536. PMID 3597387.
- ^ Fischer, W.H. & Spiess, J. (1987). „Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides”. Proc. Natl. Acad. Sci. USA. 84: 3628—3632. PMID 3473473.
- ^ Messer, M. & Ottesen, M. (1965). „Isolation and properties of glutamine cyclotransferase of dried papaya latex”. C.R. Trav. Lab. Carlsberg. 35: 1—24. PMID 5846578.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Glutaminyl-peptide+cyclotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
