Kinurenin 3-monooksigenaza
| Kinurenin 3-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.9 | ||||||||
| CAS broj | 9029-61-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Kinurenin 3-monooksigenaza (EC 1.14.13.9, kinureninska 3-hidroksilaza, kinureninska hidroksilaza, L-kinurenin-3-hidroksilaza) je enzim sa sistematskim imenom L-kinurenin,NADPH:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-kinurenin + NADPH + H+ + O2 3-hidroksi-L-kinurenin + NADP+ + H2O
Ovaj enzim je flavoprotein (FAD).
Reference[уреди | уреди извор]
- ^ de Castro, F.T., Price, J.M. and Brown, R.R. (1956). „Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine”. J. Am. Chem. Soc. 78: 2904—2905.
- ^ Okamoto, H. & Hayaishi, O. (1967). „Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria”. Biochem. Biophys. Res. Commun. 29: 394—399. PMID 6076241.
- ^ Saito, Y., Hayaishi, O. and Rothberg, S. (1957). „Studies on oxygenases: enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine”. J. Biol. Chem. 229: 921—934. PMID 13502353.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Kynurenine+3-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
