Steroid 11b-monooksigenaza
| Steroid 11b-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.15.4 | ||||||||
| CAS broj | 9029-66-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Steroid 11b-monooksigenaza (EC 1.14.15.4, steroidna 11beta-hidroksilaza, steroidna 11beta/18-hidroksilaza, oksigenaza, steroid 11beta -mono-) je enzim sa sistematskim imenom steroid,redukovani-adrenal-feredoksin:kiseonik oksidoreduktaza (11beta-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- steroid + redukovani adrenal feredoksin + O2 11beta-hidroksisteroid + oksidovani adrenal feredoksin + H2O
Ovaj enzim je hem-tiolatni protein (P-450). On takođe vrši hidroksilaciju steroida u 18-poziciji, i konvertuje 18-hidroksikortikosteron u aldosteron.
Reference
[уреди | уреди извор]- ^ Grant, J.K. & Brownie, A.C. (1955). „The role of fumarate and TPN in steroid enzymic 11β-hydroxylation”. Biochim. Biophys. Acta. 18: 433—434. PMID 13276417.
- ^ Hayano, M. & Dorfman, R.I. (1954). „On the mechanism of the C-11β-hydroxylation of steroids”. J. Biol. Chem. 211: 227—235. PMID 13211659.
- ^ Tomkins, G.M., Michael, P.J. and Curran, J.F. (1957). „Studies on the nature of steroid 11-β hydroxylation”. Biochim. Biophys. Acta. 23: 655—656. PMID 13426185.
- ^ Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. (1986). „The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis”. J. Biol. Chem. 261: 3556—3562. PMID 3485096.
- ^ Zuidweg, M.H.J. (1968). „Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata”. Biochim. Biophys. Acta. 152: 144—158. PMID 4967077.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Steroid+11beta-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
