UDP-N-acetilglukozaminska 2-epimeraza
| UDP-N-acetilglukozaminska 2-epimeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 5.1.3.14 | ||||||||
| CAS broj | 9037-71-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-N-acetilglukozaminska 2-epimeraza (EC 5.1.3.14, UDP-N-acetilglukozamin 2'-epimeraza, uridin difosfoacetilglukozaminska 2'-epimeraza, uridin difosfo-N-acetilglukozaminska 2'-epimeraza, uridin difosfat-N-acetilglukozamin-2'-epimeraza, rffE (gen), mnaA (gen), UDP-N-acetil-D-glukozamin 2-epimeraza) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin 2-epimeraza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-glukozamin UDP-N-acetil-alfa-D-manozamin
Ovaj bakterijski enzim katalizuje reverzibilnu interkonverziju UDP-GlcNAc i UDP-ManNAc.
Reference
[уреди | уреди извор]- ^ Kawamura, T., Kimura, M., Yamamori, S. and Ito, E. (1978). „Enzymatic formation of uridine diphosphate N-acetyl-D-mannosamine”. J. Biol. Chem. 253: 3595—3601. PMID 418068.
- ^ Meier-Dieter, U., Starman, R., Barr, K., Mayer, H. and Rick, P.D. (1990). „Biosynthesis of enterobacterial common antigen in Escherichia coli. Biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis”. J. Biol. Chem. 265: 13490—13497. PMID 2166030.
- ^ Morgan, P. M., Sala, R. F., and Tanner, M. E. (1997). „Eliminations in the reactions catalyzed by UDP-N-acetylglucosamine 2-epimerase”. J. Am. Chem. Soc. 119: 10269—10277.
- ^ Campbell, R.E., Mosimann, S.C., Tanner, M.E. and Strynadka, N.C. (2000). „The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases”. Biochemistry. 39: 14993—15001. PMID 11106477.
- ^ Samuel, J. & Tanner, M.E. (2004). „Active site mutants of the "non-hydrolyzing" UDP-N-acetylglucosamine 2-epimerase from Escherichia coli”. Biochim. Biophys. Acta. 1700: 85—91. PMID 15210128.
- ^ Soldo, B., Lazarevic, V., Pooley, H.M. and Karamata, D. (2002). „Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase”. J. Bacteriol. 184: 4316—4320. PMID 12107153.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- UDP-N-acetylglucosamine+2-epimerase+(non-hydrolysing) на US National Library of Medicine Medical Subject Headings (MeSH)
