Vitamin D 25-hidroksilaza
| Vitamin D 25-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.159 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Vitamin D 25-hidroksilaza (EC 1.14.13.159, vitamin D2 25-hidroksilaza, vitamin D3 25-hidroksilaza, CYP2R1) je enzim sa sistematskim imenom kalciol,NADPH:kiseonik oksidoreduktaza (25-hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj mikrozomalni enzim je izolovan iz jetre čoveka i sisara. On bioaktivira vitamin D3.
Reference[уреди | уреди извор]
- ^ Cheng, J.B., Motola, D.L., Mangelsdorf, D.J. and Russell, D.W. (2003). „De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase”. J. Biol. Chem. 278: 38084—38093. PMID 12867411.
- ^ Shinkyo, R., Sakaki, T., Kamakura, M., Ohta, M. and Inouye, K. (2004). „Metabolism of vitamin D by human microsomal CYP2R1”. Biochem. Biophys. Res. Commun. 324: 451—457. PMID 15465040.
- ^ Strushkevich, N., Usanov, S.A., Plotnikov, A.N., Jones, G. and Park, H.W. (2008). „Structural analysis of CYP2R1 in complex with vitamin D3”. J. Mol. Biol. 380: 95—106. PMID 18511070.
- ^ Zhu, J. & Deluca, H.F. (2012). „Vitamin D 25-hydroxylase - Four decades of searching, are we there yet ?”. Arch. Biochem. Biophys.: —. PMID 22310641.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Vitamin+D+25-hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)
