2',3'-Ciklični-nukleotid 3'-fosfodiestaraza
| 2',3'-Ciklični-nukleotid 3'-fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.1.4.37 | ||||||||
| CAS broj | 60098-35-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2',3'-Ciklični-nukleotid 3'-fosfodiestaraza (EC 3.1.4.37, ciklična-CMP fosfodiesteraza, 2',3'-ciklična AMP fosfodiesteraza, ciklična 2',3'-nukleotidna 3'-fosfodiesteraza, ciklična 2',3'-nukleotidna fosfodiesteraza, 2',3'-ciklična nukleozid monofosfatna fosfodiesteraza, 2',3'-ciklična nukleotidna 3'-fosfohidrolaza, CNPaza, 2',3'-ciklična nukleotidna fosfohidrolaza, 2':3'-ciklična nukleotidna 3'-fosfodiesteraza, 2':3'-CNMP-3'-aza) je enzim sa sistematskim imenom nukleozid-2',3'-ciklična-fosfat 2'-nukleotidohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nukleozid 2',3'-ciklična fosfat + H2O nukleozid 2'-fosfat
Moždani enzim deluje na 2',3'-ciklična AMP brže nego na UMP ili CMP derivate.
Reference[уреди | уреди извор]
- ^ Drummond, G.I., Iyer, N.T. and Keith, J. (1962). „Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain”. J. Biol. Chem. 237: 3535—3539.
- ^ Helfman, D.M. & Kuo, J.F. (1982). „A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2′:3′- and 3′:5′-nucleotides”. J. Biol. Chem. 257: 1044—1047. PMID 6274851.
- ^ Helfman, D.M., Shoji, M. and Kuo, J.F. (1981). „Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP”. J. Biol. Chem. 256: 6327—6334. PMID 6263914.
- ^ Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S. (1981). „Chemical, immunological and catalytic properties of 2′:3′-cyclic nucleotide 3′-phosphodiesterase purified from brain white matter”. Biochem. J. 195: 153—157. PMID 6272743.
- ^ Nishizawa, Y., Kurihara, T. and Takahashi, Y. (1980). „Spectrophotometric assay, solubilization and purification of brain 2′:3′-cyclic nucleotide 3′-phosphodiesterase”. Biochem. J. 191: 71—82. PMID 6258586.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 2',3'-cyclic-nucleotide+3'-phosphodiesterase на US National Library of Medicine Medical Subject Headings (MeSH)
